CKS1B and LDHB

Number of citations of the paper that reports this interaction (PubMedID 19786724)
39

Data Source:
BioGRID (pull down)

		CKS1B	LDHB
Description		CDC28 protein kinase regulatory subunit 1B	lactate dehydrogenase B
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Membrane Raft Extracellular Exosome Oxidoreductase Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Kinase Binding Identical Protein Binding NAD Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Cell Division	Lactate Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	Pyruvate metabolism
Drugs		Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium	NADH 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acid Oxamic Acid Stiripentol Artenimol
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		57 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9	12 interacting genes: CEBPA CKS1B CKS2 MYCBP2 OGT PEX5 POT1 PTPRF SDCBP SUMO4 TERF1 USP40
Entrez ID		1163	3945
HPRD ID		00299	01026
Ensembl ID		ENSG00000173207	ENSG00000111716
Uniprot IDs		P61024 Q5T178	A0A5F9ZHM4 P07195 Q5U077
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4	1I0Z 1T2F 7DBJ 7DBK 8QDE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomeric Loop Disassembly Telomere Capping G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Organization Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification Process Regulation Of Cellular Component Organization Chondroitin Sulfate Proteoglycan Binding Interleukin-5 Receptor Complex Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding SCF Ubiquitin Ligase Complex Circadian Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Response To Vitamin B2 C/EBP Complex Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Interleukin-5 Receptor Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly
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