CKS1B and SERTAD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CKS1B	SERTAD2
Description		CDC28 protein kinase regulatory subunit 1B	SERTA domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Cell Division	Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1
Drugs		Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)	Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 28957414 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Visceral fat ( 22589738)
Interacting Genes		57 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9	25 interacting genes: AIRIM ATG12 CDC7 CKS1B CREBBP CTNNA3 E2F1 ESPNL HELLS IGFN1 KAT2B KAT5 PARVG PIK3R3 PLA2G6 PRKAB2 STRA8 SUPT7L TFDP1 TNS2 TRIM28 XPO1 ZNF524 ZNF581 ZSCAN22
Entrez ID		1163	9792
HPRD ID		00299	18040
Ensembl ID		ENSG00000173207	ENSG00000179833
Uniprot IDs		P61024 Q5T178	Q14140
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity	DNA-binding Transcription Factor Binding Peptidyl-lysine Acetylation Acetyltransferase Activity Histone Acetyltransferase Complex N-terminal Peptidyl-lysine Acetylation Protein-lysine-acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of DNA Metabolic Process Histone Acetyltransferase Activity Protein Acetylation Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Regulation Of DNA Repair Positive Regulation Of Cell Cycle Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Recombinational Repair Transcription Coactivator Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore N-terminal Protein Amino Acid Acetylation Anoikis Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Metaphase Plate Congression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Double-strand Break Repair Attachment Of Mitotic Spindle Microtubules To Kinetochore Transcription Regulator Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Recombination Positive Regulation Of Lipid Biosynthetic Process Regulation Of Attachment Of Spindle Microtubules To Kinetochore SAGA Complex Protein Kinase Binding Cellular Response To Nutrient Levels Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Phosphatidylethanolamine Metabolic Process Chromatin Binding DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Chromosome Segregation Protein Binding
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