CKS1B and CDX4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CKS1B	CDX4
Gene Name		CDC28 protein kinase regulatory subunit 1B	caudal type homeobox 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Proliferation Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Transcription, DNA-templated Anterior/posterior Pattern Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Labyrinthine Layer Development
Pathways		Cyclin D associated events in G1 SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1 Phase Cyclin E associated events during G1/S transition SCF(Skp2)-mediated degradation of p27/p21 S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		34 interactors: ARID5A CCNA1 CCNA2 CCNB2 CDC27 CDC37 CDK1 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 HSP90AA1 IKZF1 KIAA0368 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPT3 SKP1 SKP2 SPERT SSBP1 SUMO1P1 TCF4 TRIM27 XIAP	7 interactors: CKS1B HOXA5 LMO1 LMO2 PITX1 PRKAA1 PRKAB2
Entrez ID		1163	1046
HPRD ID		00299	02065
Ensembl ID		ENSG00000173207
Uniprot IDs		P61024 Q5T178	O14627
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Checkpoint Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Mitotic DNA Integrity Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Kinase Activity Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process	Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Gene Expression Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cell Cycle Arrest Insulin Receptor Signaling Pathway Negative Regulation Of Glucose Import In Response To Insulin Stimulus Cell-cell Signaling Involved In Mammary Gland Development Branchiomeric Skeletal Muscle Development Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Camptothecin Bronchiole Development Lung Goblet Cell Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Kinase Activity Cartilage Development Intestinal Epithelial Cell Maturation Transcription From RNA Polymerase II Promoter Cellular Response To Insulin Stimulus Negative Regulation Of Sphingolipid Biosynthetic Process Lobar Bronchus Development Myoblast Fate Commitment Regulation Of Cell Cycle Response To Hormone Connective Tissue Development Regulation Of Ceramide Biosynthetic Process Transcription, DNA-templated Carnitine Shuttle Positive Regulation Of Cholesterol Biosynthetic Process Cell Cycle Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Ethanol Bronchus Development Trachea Cartilage Morphogenesis Regulation Of Protein Phosphorylation RNA Biosynthetic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse	alters auto caudal chip circuit coregulate deeper defects erythroid erythropoiesis explain facilitates hematopoiesis hox initiate insight lmo2 locus mesoderm posterior proceeds profiling program rescued sall4 seq spalt zebrafish
Tagcloud (Difference) ?		axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse	alters auto caudal chip circuit coregulate deeper defects erythroid erythropoiesis explain facilitates hematopoiesis hox initiate insight lmo2 locus mesoderm posterior proceeds profiling program rescued sall4 seq spalt zebrafish
Tagcloud (Intersection) ?