CKS1B and CDX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CKS1B	CDX4
Description		CDC28 protein kinase regulatory subunit 1B	caudal type homeobox 4
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex	Chromatin Nucleus
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Embryonic Pattern Specification Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Labyrinthine Layer Development
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1
Drugs		Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)
Interacting Genes		57 interacting genes: ARID5A CBY2 CCDC120 CCNA1 CCNB2 CCNC CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CT45A1 CUL1 DCDC2 DRC4 DUSP1 ECPAS HSF2BP HSP90AA1 IKZF1 IKZF3 INCA1 KPRP KRTAP10-9 KRTAP5-9 LDHB LHX3 LZTS1 MED12L MEOX1 MEOX2 MIPOL1 NR5A1 PAX5 PAX6 PPP1R13B PSMD9 REL ROPN1 SEPTIN3 SERTAD1 SERTAD2 SKP1 SKP2 SNRNP35 SSBP1 SUMO1P1 TCF12 TCF4 TRIM14 TRIM27 TRIM49C WASF3 XIAP ZBTB9	9 interacting genes: BANP CKS1B HOXA5 LMO1 LMO2 PITX1 PRKAA1 PRKAA2 PRKAB2
Entrez ID		1163	1046
HPRD ID		00299	02065
Ensembl ID		ENSG00000173207	ENSG00000131264
Uniprot IDs		P61024 Q5T178	O14627
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST 4YC6 7B5L 7B5M 7B5R 7NJ0 8BYA 8BYL 8OR0 8OR4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Identical Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process HMG Box Domain Binding Positive Regulation Of Macromolecule Metabolic Process Cyclin A1-CDK2 Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process Cyclin A2-CDK2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Protein Serine/threonine Kinase Activity SCF Ubiquitin Ligase Complex Meiosis I Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Somite Specification Cytoplasm Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Response To Gonadotropin-releasing Hormone Regulation Of Macromolecule Biosynthetic Process Ubiquitin Ligase Complex Scaffold Activity Meiosis I Protein Polyubiquitination Positive Regulation Of DNA Replication Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription Coregulator Binding Transcription Coactivator Activity	AMP-activated Protein Kinase Activity Nucleotide-activated Protein Kinase Complex Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Lipid Droplet Negative Regulation Of Tubulin Deacetylation Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Fatty Acid Biosynthetic Process Fatty Acid Homeostasis Hepatocyte Apoptotic Process Cellular Response To Prostaglandin E Stimulus Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Protein K6-linked Ubiquitination Response To Prostaglandin E Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process Lipid Droplet Organization Sterol Biosynthetic Process Regulation Of Release Of Cytochrome C From Mitochondria Epithelial Cell Apoptotic Process Negative Regulation Of Translational Initiation Carboxylic Acid Biosynthetic Process Cellular Response To Nutrient Levels Positive Regulation Of Translational Initiation Cellular Response To Glucose Starvation Positive Regulation Of Metabolic Process Regulation Of Glycolytic Process Regulation Of Epithelial Cell Apoptotic Process Protein Localization To Lysosome Fatty Acid Metabolic Process Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Cellular Response To Xenobiotic Stimulus Negative Regulation Of Glucosylceramide Biosynthetic Process Cellular Response To Glucose Stimulus Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Phosphatidylcholine Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?