CUL3 and RIT1

Number of citations of the paper that reports this interaction (PMID 18303015)
17

Data Source:
HPRD (in vivo)

		CUL3	RIT1
Gene Name		cullin 3	Ras-like without CAAX 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome	Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Calmodulin Binding GTP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway	Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System	Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS			Conduct disorder (interaction) ( 18846501) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4	14 interactors: AP2A1 CUL3 IFRD1 KLHL12 LRIF1 MLLT4 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2
Entrez ID		8452	6016
HPRD ID		09123	10195
Ensembl ID		ENSG00000036257	ENSG00000143622
Uniprot IDs		B7Z600 Q13618	Q92963
PDB IDs		4AP2 4APF 4EOZ 4HXI
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway	Signal Transduction Signaling Cell Communication Primary MiRNA Processing Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nodal Signaling Pathway Regulation Of Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development COPII Vesicle Coating Anatomical Structure Development Transforming Growth Factor Beta Receptor Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA COPII-coated Vesicle Budding Pericardium Development Regulation Of Cell Proliferation Response To Stimulus Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Vesicle Targeting, To, From Or Within Golgi Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Gastrulation Developmental Process In Utero Embryonic Development Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Metabolic Process Posttranscriptional Gene Silencing Protein Monoubiquitination Vesicle Targeting Localization Within Membrane
Tagcloud ?		besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Difference) ?		besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Intersection) ?		microrna