CUL3 and FOLR1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CUL3	FOLR1
Gene Name		cullin 3	folate receptor 1 (adult)
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome	Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Receptor Activity Folic Acid Binding Folic Acid Transporter Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway	Receptor-mediated Endocytosis Folic Acid Transport Folic Acid Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4	4 interactors: CUL3 IRAK3 LYN NCAPH2
Entrez ID		8452	2348
HPRD ID		09123	00638
Ensembl ID		ENSG00000036257	ENSG00000110195
Uniprot IDs		B7Z600 Q13618	P15328
PDB IDs		4AP2 4APF 4EOZ 4HXI	4KM6 4KM7 4KMX 4LRH
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway	Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Oligodendrocyte Progenitor Proliferation Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Mast Cell Proliferation Negative Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Protein Autophosphorylation Tolerance Induction To Self Antigen Fc Receptor Mediated Inhibitory Signaling Pathway Trophectodermal Cellular Morphogenesis Positive Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Macrophage Cytokine Production Regulation Of Phosphorylation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of MAP Kinase Activity Immune Response-inhibiting Signal Transduction Regulation Of Phosphorus Metabolic Process Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Tolerance Induction Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Mast Cell Proliferation Positive Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Organelle Localization
Tagcloud ?		besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?