CUL3 and CDC34

Number of citations of the paper that reports this interaction (PMID 19256485)
6

Data Source:
BioGRID (pull down)

		CUL3	CDC34
Gene Name		cullin 3	cell division cycle 34
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Gene Ontology Annotations	Cellular Component	Golgi Membrane Nucleoplasm Polar Microtubule Cytosol Membrane Cul3-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Trophectodermal Cellular Morphogenesis Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Cell Cycle Arrest Mitotic Metaphase Plate Congression Integrin-mediated Signaling Pathway Gastrulation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Cell Migration Protein Ubiquitination Stem Cell Division Positive Regulation Of Cytokinesis Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Cellular Protein Modification Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of CAMP-mediated Signaling Response To Growth Factor Protein K48-linked Ubiquitination Positive Regulation Of Inclusion Body Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Hedgehog degradation of DVL Class I MHC mediated antigen processing & presentation Signaling by WNT in cancer Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ABTB1 ABTB2 APP ARHGEF12 BTBD10 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 COMMD1 DCUN1D1 DCUN1D4 DYRK4 EFNB1 FOLR1 GMCL1 GPS1 HLA-DMB HSF2 KCTD13 KCTD5 KCTD6 KCTD9 KLHL12 KLHL2 KLHL20 KLHL3 KLHL42 KLHL5 NEDD8 OLIG2 PDIA2 RBX1 RCBTB1 RCBTB2 RHOBTB3 RIT1 RNF7 SHKBP1 SUMO2 SUMO3 TCEB1 TNFAIP1 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2M WNT7B ZMAT4	45 interactors: ANAPC11 ATF5 BTRC CCNE1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCH1 MARCH2 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARG RBX1 RELA RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM21 TRIM28 UBA1 UBB VHL WWP2 ZFAND6 ZNRF1
Entrez ID		8452	997
HPRD ID		09123	00306
Ensembl ID		ENSG00000036257	ENSG00000099804
Uniprot IDs		B7Z600 Q13618	P49427
PDB IDs		4AP2 4APF 4EOZ 4HXI	2OB4 3RZ3
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein Neddylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Monoubiquitination Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Protein Homooligomerization Protein K11-linked Ubiquitination Proteolysis Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Oligomerization Response To Growth Factor Regulation Of Cellular Process Protein Complex Assembly DNA Replication Cellular Response To Stress Positive Regulation Of Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle MyD88-independent Toll-like Receptor Signaling Pathway	Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Metabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein Polyubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Metabolic Process Viral Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Protein Monoubiquitination Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Phase Transition Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Gene Expression Cell Cycle Phase Transition Cellular Response To Oxygen Levels Cellular Response To Stimulus Regulation Of Protein Catabolic Process Response To Stimulus Cellular Response To Stress Regulation Of Protein Stability Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Cycle Negative Regulation Of RNA Biosynthetic Process Cell Cycle Regulation Of Transcription, DNA-templated Apoptotic Process Regulation Of Nucleic Acid-templated Transcription G1/S Transition Of Mitotic Cell Cycle Regulation Of RNA Biosynthetic Process Programmed Cell Death Regulation Of Protein Metabolic Process
Tagcloud ?		besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	apparatus assemble associates box cdk cdk2 cerevisiae clock conjugating conjugation cul cullin dependency e3 facilitates governed imply ligase multiprotein p19 p45 periodic saccharomyces scf scfcdc4 skp1 skp2 tight ubiquitin
Tagcloud (Difference) ?		besides bioactive bioinformatics btb btbd3 candidate connectivity degs dehydrogenase dysfunctional dysregulated eicosanoid follistatin fst informatics islets latent ligases ltbp1 microrna micrornas nodes pdgfra poz prostaglandin sanguinarine t2d thiorphan zadh2	apparatus assemble associates box cdk cdk2 cerevisiae clock conjugating conjugation cul cullin dependency e3 facilitates governed imply ligase multiprotein p19 p45 periodic saccharomyces scf scfcdc4 skp1 skp2 tight ubiquitin
Tagcloud (Intersection) ?