CUL3 and GABARAPL2

Number of citations of the paper that reports this interaction (PubMedID 25684205)
0

Data Source:
BioGRID (pull down)

		CUL3	GABARAPL2
Description		cullin 3	GABA type A receptor associated protein like 2
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Motile Cilium Sperm Flagellum Cell Projection Extracellular Exosome Mitotic Spindle Postsynapse Glutamatergic Synapse	Golgi Membrane Autophagosome Membrane Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity	SNARE Binding Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis In Utero Embryonic Development Kidney Development Trophectodermal Cellular Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Response To Stress Inflammatory Response Response To Oxidative Stress Mitotic Metaphase Chromosome Alignment Signal Transduction Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Wnt Signaling Pathway Vesicle-mediated Transport Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Nutrient Levels Positive Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Cell Division Protein Autoubiquitination Type I Interferon-mediated Signaling Pathway Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Regulation Of Primary Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Postsynapse RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Autophagosome Assembly Mitophagy Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Positive Regulation Of ATP-dependent Activity Protein Localization To Endoplasmic Reticulum Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RHOBTB3 ATPase cycle KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation SPOP-mediated proteasomal degradation of PD-L1(CD274)	Macroautophagy TBC/RABGAPs
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 25056061 28991256 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Age at first sexual intercourse ( 34211149) Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		66 interacting genes: ABTB1 ABTB2 ARHGEF12 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CEBPA CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 FOLR1 GABARAP GABARAPL1 GABARAPL2 GLUD1 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD7 KLHL12 KLHL22 KLHL42 KLHL6 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDIA2 PDPK1 RBBP8 RBX1 RCBTB1 RHOBTB3 RIT1 RNF7 SHKBP1 SNX6 SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 WNT7B ZMAT4	103 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP APPL1 ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 AZI2 BCL2L13 BICC1 BNIP3L BRD9 BSDC1 CALCOCO1 CALCOCO2 CARS2 CDC37 CEBPA CLN8 CUL3 DYNLL1 DYNLL2 EGFR ERBB2 ERBB3 ERBB4 FUNDC1 GIMAP6 GOSR1 GPR37 HAP1 INSYN1 KASH5 KBTBD6 KBTBD7 KIAA1958 KIF16B KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 LZTR1 MAP4K2 MCPH1 MEF2A MEFV MLX MRPL49 MYBPC1 NBR1 NCOR1 NEDD4 NPSR1 NSF NUDT15 OPTN OSBPL3 OSBPL7 PDLIM1 PTPRA RAP1A RAP2A RB1CC1 RCN2 RESF1 RETREG1 RETREG3 RPS2 SCYL3 SEPTIN3 SGTA SIK2 SMO SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TEX264 TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TRIM45 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ ZBTB2 ZNF774
Entrez ID		8452	11345
HPRD ID		09123	16246
Ensembl ID		ENSG00000036257	ENSG00000034713
Uniprot IDs		B7Z600 Q13618	P60520
PDB IDs		2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8I79 8K8T 8K9I 8KHP 8U80 8U81 8U82 8U83 8U84	4CO7 6H8C 7LK3 7YO8 8Q6Q
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Neddylation Post-translational Protein Modification Cellular Response To Nitrogen Starvation Protein Modification Process Cullin Family Protein Binding Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Phosphatidylethanolamine Binding Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Neddylation Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Mitophagy Protein K48-linked Ubiquitination Protein Tag Activity Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Starvation Ubiquitin-protein Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Autophagosome Maturation Protein Metabolic Process Protein Polyubiquitination Cytoplasm Autophagosome Assembly Autophagosome Membrane Response To Starvation Autophagosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Binding Ubiquitin Conjugating Enzyme Binding Macromolecule Catabolic Process Autophagosome Proteasomal Protein Catabolic Process Nucleus Mitotic Cell Cycle Phase Transition GABA Receptor Binding Cytosol Macroautophagy	Autophagosome Autophagy Macroautophagy Autophagy Of Mitochondrion Mitophagy Autophagosome Assembly Autophagosome Organization Catabolic Process Nucleophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Microautophagy Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Cytosol Reticulophagy Cytoplasm Aggrephagy Cytoplasmic Vesicle Intracellular Protein Localization Organelle Assembly Atg1/ULK1 Kinase Complex Organelle Organization Positive Regulation Of Macroautophagy Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Protein-phosphatidylethanolamide Deconjugating Activity Autophagosome Membrane Macromolecule Catabolic Process Response To Stress Regulation Of Signal Transduction Protein Delipidation Regulation Of Signaling Receptor Complex Protein Modification Process Protein K48-linked Ubiquitination Response To Mitochondrial Depolarisation Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Regulation Of Cell Communication Establishment Of Protein Localization Protein Binding Phagophore Assembly Site Membrane ERBB2 Signaling Pathway Regulation Of MAPK Cascade Protein Metabolic Process Identical Protein Binding
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