CUL3 and RBX1

Number of citations of the paper that reports this interaction (PubMedID 36964131)
96

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CUL3	RBX1
Description		cullin 3	ring-box 1
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Motile Cilium Sperm Flagellum Cell Projection Extracellular Exosome Mitotic Spindle Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein-containing Complex Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis In Utero Embryonic Development Kidney Development Trophectodermal Cellular Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Response To Stress Inflammatory Response Response To Oxidative Stress Mitotic Metaphase Chromosome Alignment Signal Transduction Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Wnt Signaling Pathway Vesicle-mediated Transport Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Nutrient Levels Positive Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Cell Division Protein Autoubiquitination Type I Interferon-mediated Signaling Pathway Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Regulation Of Primary Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Postsynapse RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle MAPK Cascade Protein Polyubiquitination Mitophagy Epithelial To Mesenchymal Transition DNA Repair Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Response To Oxidative Stress Lysosome Organization Spermatogenesis Regulation Of Mitotic Cell Cycle Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV MiRNA-mediated Gene Silencing By MRNA Destabilization P38MAPK Cascade TORC1 Signaling T Cell Activation Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Translation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Cellular Response To Chemical Stress Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Mitophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RHOBTB3 ATPase cycle KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation SPOP-mediated proteasomal degradation of PD-L1(CD274)	Recognition of DNA damage by PCNA-containing replication complex Prolactin receptor signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Degradation of DVL Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Orc1 removal from chromatin Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Potential therapeutics for SARS Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 25056061 28991256 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Crohn's disease ( 22936669) LDL cholesterol levels ( 32203549) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		66 interacting genes: ABTB1 ABTB2 ARHGEF12 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CEBPA CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 FOLR1 GABARAP GABARAPL1 GABARAPL2 GLUD1 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD7 KLHL12 KLHL22 KLHL42 KLHL6 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDIA2 PDPK1 RBBP8 RBX1 RCBTB1 RHOBTB3 RIT1 RNF7 SHKBP1 SNX6 SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 WNT7B ZMAT4	78 interacting genes: APP ARIH1 ARIH2 CAND1 CAND2 CCND1 CCNK CDC34 CFLAR COPS4 COPS6 CSNK1E CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 ELOB ELOC ERBIN ERCC8 FBH1 FBXL2 FBXO45 FBXW8 FRZB GHR GLMN GPS1 HAX1 KCTD17 KEAP1 KLHDC2 KLHL22 KLHL3 KPNB1 KRTAP12-2 MAGEC2 MAP3K20 MAP3K7 MAPK8IP2 MKNK2 MYB NEURL2 OS9 PBX4 PML PRAME RHOBTB3 RNF126 RPS6KB1 SERTAD1 SKP1 SMAD3 SNAI1 TAB1 TRIM27 TRIM74 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2L3 UBE2L6 UBE2M UBE2N UBE2R2 VHL VRK2
Entrez ID		8452	9978
HPRD ID		09123	06794
Ensembl ID		ENSG00000036257	ENSG00000100387
Uniprot IDs		B7Z600 Q13618	P62877
PDB IDs		2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8I79 8K8T 8K9I 8KHP 8U80 8U81 8U82 8U83 8U84	1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52 4P5O 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 6TTU 7B5L 7B5M 7B5N 7B5S 7OKQ 7PLO 7Z8B 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8B3G 8B3I 8CDJ 8CDK 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8IJ1 8JAQ 8JAS 8JAV 8JE1 8K9I 8KHP 8OR0 8OR2 8OR3 8OR4 8PQL 8Q7E 8Q7H 8Q7R 8QU8 8R5H 8RHZ 8RWZ 8RX0 8UBU 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 9JKB 9KBD
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Neddylation Post-translational Protein Modification Cellular Response To Nitrogen Starvation Protein Modification Process Cullin Family Protein Binding Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Phosphatidylethanolamine Binding Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Neddylation Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Mitophagy Protein K48-linked Ubiquitination Protein Tag Activity Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Starvation Ubiquitin-protein Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Autophagosome Maturation Protein Metabolic Process Protein Polyubiquitination Cytoplasm Autophagosome Assembly Autophagosome Membrane Response To Starvation Autophagosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Binding Ubiquitin Conjugating Enzyme Binding Macromolecule Catabolic Process Autophagosome Proteasomal Protein Catabolic Process Nucleus Mitotic Cell Cycle Phase Transition GABA Receptor Binding Cytosol Macroautophagy	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Monoubiquitination Cytosol Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity Nucleus Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Ubiquitin-like Protein Transferase Activity Cell Cycle G1/S Phase Transition Cell Cycle Phase Transition Transferase Activity SCF Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Response To Stress Protein K63-linked Ubiquitination Mitotic Cell Cycle Phase Transition Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex ATP Binding Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Intracellular Signal Transduction SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of TORC1 Signaling
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