DCTN5 and NINL

Number of citations: 58 (PubMedID 26485645)
Data Source: BioGRID (two hybrid, affinity chromatography technology), HPRD (two hybrid)

		DCTN5	NINL
Name		dynactin subunit 5	ninein like
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Nuclear Membrane	Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Ventricular Septum Development Aorta Development Coronary Vasculature Development	Microtubule Anchoring At Centrosome
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
GWAS		Bipolar disorder ( 17554300 )	Brain morphology (MOSTest) ( 32665545 ) Macular thickness ( 30535121 ) Telomere length ( 30185882 ) Urate levels ( 31578528 )
Novel Interactors		5 novel interactors: C16orf82 CHP2 COG7 EARS2 KDM8	3 novel interactors: APMAP POLR3F SEC23B
Interacting Genes		5 interacting genes: DYNLL1 FATE1 NINL PMEPA1 RBPMS	52 interacting genes: AKAP17A APEX2 AURKB CBY2 CCDC146 CCDC33 CCHCR1 CLEC1B DCTN5 ELOA ERBB2 EWSR1 EZH2 FAM107A FAM161A GCC1 GPKOW HAUS1 JUNB KANSL1 KAT5 KAT7 KRT1 L3MBTL4 LRSAM1 LZTS2 MAD1L1 MBIP MCM10 PLK1 PRPF18 PRPF3 RBM41 RCOR3 RGS2 RIBC2 RNF40 SH2D4A SH3BP5L SYT17 TCEANC TNNT1 TSC1 TSPYL4 UTP14A YJU2B ZFC3H1 ZFHX3 ZNF250 ZNF417 ZNF426 ZNF646
Entrez ID		84516	22981
HPRD ID		14551	11120
Ensembl ID		ENSG00000166847	ENSG00000101004
Uniprot IDs		Q9BTE1	Q9Y2I6
PDB IDs		5NW4	Not available
GO Terms Enriched among Interactors		None	Mitotic Spindle Pole Nucleus Protein Binding Chromosome, Centromeric Region Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Pole Regulation Of Metaphase Plate Congression Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone Acetyltransferase Complex Positive Regulation Of Chromosome Segregation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Histone H4K16 Acetyltransferase Activity Spindle Microtubule Protein Localization To Chromosome Regulation Of Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Cytoskeleton Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Spindle Midzone Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Negative Regulation Of Cell Cycle Phase Transition Zinc Ion Binding Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation RNA Splicing Centrosome