DCTN5 and KDM8

		DCTN5	KDM8
Description		dynactin subunit 5	lysine demethylase 8
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Dynactin Complex Nuclear Membrane	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Binding	P53 Binding Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding Peptidase Activity Oxidoreductase Activity Hydrolase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Peptidyl-arginine 3-dioxygenase Activity
	Biological Process	Ventricular Septum Development Aorta Development Coronary Vasculature Development	G2/M Transition Of Mitotic Cell Cycle In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Proteolysis Regulation Of Gene Expression Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Rhythmic Process Regulation Of Signal Transduction By P53 Class Mediator
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Protein hydroxylation
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Asthma ( 31619474 31959851) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)
Interacting Genes		5 interacting genes: DYNLL1 FATE1 NINL PMEPA1 RBPMS	8 interacting genes: DDIT4L H3C1 HEATR5B IFT20 ISY1 MEOX2 NUBPL PCYT2
Entrez ID		84516	79831
HPRD ID		14551	07836
Ensembl ID		ENSG00000166847	ENSG00000155666
Uniprot IDs		Q9BTE1	A0A0S2Z5P8 A0A0S2Z5T1 Q8N371
PDB IDs		5NW4	3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N 7DYT 7DYU 7DYV 7DYW 7DYX 7UQ3
Enriched GO Terms of Interacting Partners?
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