MAP3K10 and PHB1

Number of citations of the paper that reports this interaction (PubMedID 9629920)
0

Data Source:
HPRD (in vitro)

		MAP3K10	PHB1
Description		mitogen-activated protein kinase kinase kinase 10	prohibitin 1
Image
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Early Endosome Plasma Membrane Cell Surface Membrane Mitochondrial Prohibitin Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity	Complement Component C3a Binding Complement Component C3b Binding Transcription Corepressor Activity Protein Binding Enzyme Binding Proteinase Activated Receptor Binding Histone Deacetylase Binding Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Mitochondrion Organization Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Growth Positive Regulation Of Interleukin-17 Production RIG-I Signaling Pathway Epigenetic Regulation Of Gene Expression B Cell Activation Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Symbiont Entry Into Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Progesterone Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interleukin-6 DNA Biosynthetic Process T-helper 17 Type Immune Response Antiviral Innate Immune Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways			RAF activation Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Processing of SMDT1 Signaling downstream of RAS mutants
Drugs		Fostamatinib	Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	27 interacting genes: ANXA2 BCAS3 CASC3 CCL5 CD40LG COX6C E2F1 ESR1 HDAC1 LONRF3 MAP1LC3A MAP3K10 MCM2 NCOR1 PTEN RAF1 RB1 RBL1 RBL2 SEC22A SIN3A SMARCA2 SMARCA4 ST14 SUMO4 TP53 XPO1
Entrez ID		4294	5245
HPRD ID		02533	01454
Ensembl ID		ENSG00000130758	ENSG00000167085
Uniprot IDs		Q02779	A8K401 P35232 Q53FV0
PDB IDs		2RF0	8RRH
Enriched GO Terms of Interacting Partners?		MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration	Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Transcription Regulator Complex Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Regulation Of Primary Metabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Enzyme Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Heterochromatin Formation Rhythmic Process Transcription Repressor Complex Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Epigenetic Regulation Of Gene Expression Circadian Behavior Promoter-specific Chromatin Binding Regulation Of Stem Cell Population Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of MiRNA Transcription
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