BRSK1 and PAK1

Number of citations of the paper that reports this interaction (PMID 22669945)
7

Data Source:
BioGRID (enzymatic study)

		BRSK1	PAK1
Gene Name		BR serine/threonine kinase 1	p21 protein (Cdc42/Rac)-activated kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Synaptic Vesicle Cell Junction	Ruffle Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Intercalated Disc Z Disc Axon Dendrite Growth Cone Filamentous Actin Nuclear Membrane Ruffle Membrane Protein Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Gamma-tubulin Binding Tau-protein Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Neurotransmitter Secretion Axonogenesis Response To UV Response To Ionizing Radiation Establishment Of Cell Polarity Neuron Differentiation G2 DNA Damage Checkpoint Centrosome Duplication	MAPK Cascade Mitotic Cell Cycle Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Exocytosis Apoptotic Process Axon Guidance Neuromuscular Junction Development Dendrite Development Signal Transduction By Phosphorylation T Cell Costimulation Actin Cytoskeleton Reorganization Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Wound Healing Receptor Clustering Positive Regulation Of JUN Kinase Activity Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Branching Morphogenesis Of An Epithelial Tube Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Cell Proliferation Involved In Contact Inhibition
Pathways			Axon guidance Costimulation by the CD28 family FCERI mediated MAPK activation L1CAM interactions VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Generation of second messenger molecules Signal transduction by L1 Semaphorin interactions CD28 co-stimulation CD28 dependent Vav1 pathway TCR signaling DSCAM interactions Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		8 interactors: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A PAK1 UBC WEE1	83 interactors: ABI3 ACTA1 ACVR1 AKT1 APP ARHGEF2 ARHGEF6 ARHGEF7 ARPC1B BAD BAIAP2 BMPR1B BMX BRSK1 C5orf42 CASP1 CDC42 CDK11B CDK5 CDK5R1 CHORDC1 COL1A1 CRIPAK CSNK2A1 CSNK2A2 DSCAM DYNLL1 DYNLL2 DYRK1B EGFR ELF3 ERBB2 ESR1 FLNA FOXL2 FOXO1 FRS2 GIT2 GRB2 HGS HIST1H3A HIST1H4A HSP90AA1 LIMK1 MAP2K1 MAP3K1 MAPK1 MBP MYLK MYNN MYO6 NCK1 NCK2 NF2 OXSR1 PAK1IP1 PDPK1 PLCG1 PPM1F PRKCD PXN RAC1 RAF1 RHOJ RHOU SHC1 SMAD1 SMAD2 SMAD4 SMURF1 SORBS2 SORBS3 SYN1 TGFBR1 TGFBR2 TGM2 YWHAG YWHAZ ZBTB18 ZC3H7A ZNF418 ZNF823 ZNF83
Entrez ID		84446	5058
HPRD ID		12533	03995
Ensembl ID		ENSG00000160469	ENSG00000149269
Uniprot IDs		Q8TDC3	B3KNX7 Q13153
PDB IDs			1F3M 1YHV 1YHW 1ZSG 2HY8 2QME 3DVP 3FXZ 3FY0 3Q4Z 3Q52 3Q53 4DAW 4EQC
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Cell Division DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation JNK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Kinase Activity Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Regulation Of Phosphorylation T Cell Receptor Signaling Pathway Viral Process Signal Transduction By P53 Class Mediator Positive Regulation Of Transferase Activity Cellular Heat Acclimation Positive Regulation Of Histone H3-K9 Acetylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Protein Ubiquitination	Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Anatomical Structure Morphogenesis Regulation Of Cellular Component Organization Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Differentiation Cell Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Anatomical Structure Development System Development Regulation Of Kinase Activity Intracellular Signal Transduction Developmental Process Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Organelle Organization Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Multicellular Organismal Development Neurogenesis Axon Guidance Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Axonogenesis Cell Communication Cell Projection Organization Tissue Development Cell Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Metabolic Process Signaling Neuron Projection Morphogenesis Axon Development Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Defense Response
Tagcloud ?		aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Difference) ?		aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	advance belonging cdc2 cdc42 coordinate coordinates coordinating cot1 delays dystrophy encodes fission genetically interphase maintain maintains mitosis mitotic morphogenesis myotonic orb2 orb6 p34 polarity polarized ras1 shape shk1 threonine
Tagcloud (Intersection) ?