BRSK1 and HSD17B7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		BRSK1	HSD17B7
Gene Name		BR serine/threonine kinase 1	hydroxysteroid (17-beta) dehydrogenase 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Synaptic Vesicle Cell Junction	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Gamma-tubulin Binding Tau-protein Kinase Activity	3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity Prolactin Receptor Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Neurotransmitter Secretion Axonogenesis Response To UV Response To Ionizing Radiation Establishment Of Cell Polarity Neuron Differentiation G2 DNA Damage Checkpoint Centrosome Duplication	Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Cholesterol biosynthesis Metabolism of lipids and lipoproteins
Drugs			NADH
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		8 interactors: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A PAK1 UBC WEE1	6 interactors: AGPAT6 BRSK1 CA1 DTYMK GORAB VKORC1
Entrez ID		84446	51478
HPRD ID		12533	05996
Ensembl ID		ENSG00000160469	ENSG00000132196
Uniprot IDs		Q8TDC3	P56937
PDB IDs
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Cell Division DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation JNK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Kinase Activity Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Regulation Of Phosphorylation T Cell Receptor Signaling Pathway Viral Process Signal Transduction By P53 Class Mediator Positive Regulation Of Transferase Activity Cellular Heat Acclimation Positive Regulation Of Histone H3-K9 Acetylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Protein Ubiquitination	Nucleoside Monophosphate Phosphorylation DTDP Biosynthetic Process Small Molecule Metabolic Process DUDP Biosynthetic Process Glandular Epithelial Cell Maturation Vitamin K Metabolic Process DTTP Biosynthetic Process Cofactor Metabolic Process Deoxyribonucleoside Diphosphate Metabolic Process Nucleoside Diphosphate Biosynthetic Process CDP-diacylglycerol Biosynthetic Process CDP-diacylglycerol Metabolic Process Peptidyl-glutamic Acid Carboxylation Deoxyribonucleotide Biosynthetic Process Diacylglycerol Metabolic Process Nucleobase-containing Small Molecule Interconversion Epithelial Cell Maturation Phosphatidylcholine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Regulation Of Body Fluid Levels Glandular Epithelial Cell Development Bicarbonate Transport Secretion Centrosome Duplication G2 DNA Damage Checkpoint One-carbon Metabolic Process Anatomical Structure Development Quinone Metabolic Process Drug Metabolic Process Triglyceride Biosynthetic Process Columnar/cuboidal Epithelial Cell Development Glandular Epithelial Cell Differentiation Myoblast Differentiation Deoxyribonucleotide Metabolic Process Phosphatidylcholine Metabolic Process Pyrimidine Nucleotide Biosynthetic Process Developmental Process Centrosome Cycle Lactation Nucleotide Phosphorylation Response To Cadmium Ion Nucleoside Diphosphate Metabolic Process Acyl-CoA Metabolic Process Cellular Metabolic Process Phosphate-containing Compound Metabolic Process Pyrimidine Nucleotide Metabolic Process Cellular Ketone Metabolic Process Organophosphate Metabolic Process
Tagcloud ?		aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	1a akr1c3 androgenic androstenedione comt cyp19a1 cyp1b1 cyp3a5 e1s ers esr2 estrogens extents gper gstp1 hec hieec hsd3b2 hydroxyestrogens ishikawa metabolized nqo2 quinones sulfatase sult1a1 sult2b1 ugt2b7
Tagcloud (Difference) ?		aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	1a akr1c3 androgenic androstenedione comt cyp19a1 cyp1b1 cyp3a5 e1s ers esr2 estrogens extents gper gstp1 hec hieec hsd3b2 hydroxyestrogens ishikawa metabolized nqo2 quinones sulfatase sult1a1 sult2b1 ugt2b7
Tagcloud (Intersection) ?