BRSK1 and CDC25B

Number of citations of the paper that reports this interaction (PubMedID 15150265)
0

Data Source:
HPRD (in vitro)

		BRSK1	CDC25B
Description		BR serine/threonine kinase 1	cell division cycle 25B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton Synaptic Vesicle Postsynaptic Density Cell Junction Cytoplasmic Vesicle Cell Projection Synapse Presynaptic Active Zone Cholinergic Synapse Distal Axon	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neurotransmitter Secretion Nervous System Development Axonogenesis Associative Learning Response To UV Response To Ionizing Radiation Regulation Of Synaptic Vesicle Priming Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Central Nervous System Neuron Differentiation Establishment Of Cell Polarity Neuron Differentiation Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Regulation Of Axonogenesis Centrosome Duplication Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Clustering	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Female Meiosis I Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cytokinesis Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways			Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs			L-cysteic acid
Diseases
GWAS		Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 26414677)	Basophil percentage of granulocytes ( 27863252) Cognitive decline rate in late mild cognitive impairment ( 26252872) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) SAPHO syndrome ( 33816493)
Interacting Genes		8 interacting genes: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A MAPT PAK1 WEE1	28 interacting genes: AATK AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CDK5 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR PSME3 SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		84446	994
HPRD ID		12533	00307
Ensembl ID		ENSG00000160469	ENSG00000101224
Uniprot IDs		Q8TDC3	B3KS38 B4DIG0 B4DQZ3 B4DRC3 E1YMX4 G8JLH2 P30305
PDB IDs			1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle G2/M Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Microtubule Polymerization Regulation Of G2/MI Transition Of Meiotic Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Protein Polymerization Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Growth Positive Regulation Of Mitotic Cell Cycle Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Protein Kinase Binding Cell Cycle Phase Transition Positive Regulation Of Meiotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Cell Growth Positive Regulation Of Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Growth Regulation Of Organelle Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Growth Positive Regulation Of Axon Extension Positive Regulation Of Cell Cycle Process Cellular Response To Heat Tubulin Binding Microtubule-based Process Regulation Of Meiotic Cell Cycle Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Organelle Organization	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Kinase Activity Protein Phosphorylation Phosphoserine Residue Binding Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Cytoplasm Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Protein Domain Specific Binding Regulation Of Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition Rhythmic Process Cell Cycle Phase Transition Regulation Of Cell Cycle Process Transferase Activity DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Signal Transduction Cytosol Intracellular Signaling Cassette Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle MAPK Cascade ATP Binding Signal Transduction In Response To DNA Damage Nucleus Regulation Of Intracellular Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Cell Communication Regulation Of Primary Metabolic Process Regulation Of Signaling Protein Modification Process Nucleoplasm Centrosome Estrogen Response Element Binding Protein Sequestering Activity Negative Regulation Of RNA Metabolic Process Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteasomal Protein Catabolic Process
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