BRSK1 and CDC25B

Number of citations of the paper that reports this interaction (PMID 15150265)
11

Data Source:
HPRD (in vitro)

		BRSK1	CDC25B
Gene Name		BR serine/threonine kinase 1	cell division cycle 25B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Synaptic Vesicle Cell Junction	Spindle Pole Nucleoplasm Cytoplasm Centrosome Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Gamma-tubulin Binding Tau-protein Kinase Activity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Neurotransmitter Secretion Axonogenesis Response To UV Response To Ionizing Radiation Establishment Of Cell Polarity Neuron Differentiation G2 DNA Damage Checkpoint Centrosome Duplication	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation Protein Phosphorylation Mitotic Nuclear Division Female Meiosis I Positive Regulation Of Cell Proliferation Positive Regulation Of Cytokinesis Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Cell Division
Pathways			Cyclin A/B1 associated events during G2/M transition G2/M Transition S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases Cyclin B2 mediated events Cell Cycle, Mitotic
Drugs			Double Oxidized Cysteine Cysteinesulfonic Acid Methyl Mercury Ion
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619)
Protein-Protein Interactions		8 interactors: BRCA1 CDC25B CDC25C HSD17B7 HSPA1A PAK1 UBC WEE1	25 interactors: AR AURKA BRSK1 BRSK2 CDC14A CDK1 CDK2 CHEK1 CREBBP CSNK2A1 CSNK2B ESR1 FHL3 KAT2B MAPK14 MAPK9 MAPKAPK2 MELK PGR SFN YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		84446	994
HPRD ID		12533	00307
Ensembl ID		ENSG00000160469	ENSG00000101224
Uniprot IDs		Q8TDC3	B3KS38 B4DIG0 B4DRC3 G8JLH2 P30305 Q6MZW8
PDB IDs			1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Protein Ubiquitination Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Process Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Kinase Activity Positive Regulation Of Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Cell Division DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation JNK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Kinase Activity Regulation Of Cell Cycle Arrest Negative Regulation Of Protein Ubiquitination Regulation Of Phosphorylation T Cell Receptor Signaling Pathway Viral Process Signal Transduction By P53 Class Mediator Positive Regulation Of Transferase Activity Cellular Heat Acclimation Positive Regulation Of Histone H3-K9 Acetylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Protein Ubiquitination	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Intrinsic Apoptotic Signaling Pathway G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Programmed Cell Death Cell Cycle Process Cell Death Death Multicellular Organismal Development Developmental Process System Development Signaling Anatomical Structure Development Regulation Of Apoptotic Process Cell Communication Phosphorylation Cellular Response To Stimulus Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Positive Regulation Of Apoptotic Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Cell Cycle Checkpoint Regulation Of Protein Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Signal Transduction DNA Damage Checkpoint Regulation Of Intracellular Transport Regulation Of Signal Transduction Cellular Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transport Mitotic Cell Cycle Regulation Of Cellular Localization Histone Phosphorylation G2 DNA Damage Checkpoint Response To Stimulus
Tagcloud ?		aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	anticancer box constituent contrary elucidated exhibits forkhead foxm1 g2 garnered glioma gliomas inactivation m1 medicinal natural nevertheless oncogenic p21cip1 p27kip1 plumbagin plumbago quinonoid root sifoxm1 survivin transactivation transfection zeylanica
Tagcloud (Difference) ?		aicar ampk ampkbeta blunted brsk2 c433s caax cys433 farnesylated farnesylation fertile imidazolecarboxamide knockin lkb1 lkb1c433s lkb1s431a mark4 mimetic myristoylation nuak nuak1 phenformin prenylated raises riboside s431a ser431 sik3 snf1	anticancer box constituent contrary elucidated exhibits forkhead foxm1 g2 garnered glioma gliomas inactivation m1 medicinal natural nevertheless oncogenic p21cip1 p27kip1 plumbagin plumbago quinonoid root sifoxm1 survivin transactivation transfection zeylanica
Tagcloud (Intersection) ?