HSPD1 and RASA1

Number of citations of the paper that reports this interaction (PubMedID 1347942)
36

Data Source:
HPRD (in vivo)

		HSPD1	RASA1
Description		heat shock protein family D (Hsp60) member 1	RAS p21 protein activator 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Coated Vesicle Secretory Granule Protein-containing Complex Intracellular Membrane-bounded Organelle Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece Sperm Plasma Membrane Migrasome	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Protein-folding Chaperone Binding Cysteine-type Endopeptidase Activator Activity ATP-dependent Protein Folding Chaperone	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding
	Biological Process	Positive Regulation Of Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Folding 'de Novo' Protein Folding Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Positive Regulation Of Interferon-alpha Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Mitochondrial Unfolded Protein Response Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation Biological Process Involved In Interaction With Symbiont Cellular Response To Interleukin-7 Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs		Copper
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)	RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		58 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CFTR CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT FNDC3B H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 OGT PDE4B PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG	93 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		3329	5921
HPRD ID		00318	00745
Ensembl ID		ENSG00000144381	ENSG00000145715
Uniprot IDs		A0A024R3X4 P10809	P20936 Q59GK3
PDB IDs		4PJ1 6HT7 6MRC 6MRD 7AZP 7L7S 8G7J 8G7K 8G7L 8G7M 8G7N 8G7O 8U39	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Signaling Cytosol Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Signal Transduction Regulation Of Proteolysis Regulation Of Calcium-mediated Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Signaling Identical Protein Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-2 Production Protein Heterodimerization Activity Regulation Of Protein Localization Glutamatergic Synapse Response To Stress Regulation Of Cytokine Production Fibroblast Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Proteolysis Regulation Of Reactive Oxygen Species Metabolic Process Integrin Alpha3-beta1 Complex Membrane Raft Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Neuron Projection Organization Regulation Of Programmed Cell Death Response To Yeast Cognition Regulation Of Cellular Localization Keratin Filament Regulation Of Multicellular Organismal Process	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion
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