HSPD1 and MGAT3

Data Source: HiPPIP (Novel)

		HSPD1	MGAT3
Name		heat shock protein family D (Hsp60) member 1	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Coated Vesicle Secretory Granule Protein-containing Complex Intracellular Membrane-bounded Organelle Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece Sperm Plasma Membrane Migrasome	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Protein-folding Chaperone Binding Cysteine-type Endopeptidase Activator Activity ATP-dependent Protein Folding Chaperone	Beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity
	Biological Process	Positive Regulation Of Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Folding 'de Novo' Protein Folding Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Positive Regulation Of Interferon-alpha Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Mitochondrial Unfolded Protein Response Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation Biological Process Involved In Interaction With Symbiont Cellular Response To Interleukin-7 Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	N-acetylglucosamine Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Intracellular Protein Localization Regulation Of Cell Migration Cellular Response To Oxidative Stress Amyloid-beta Metabolic Process Cognition Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Reactions specific to the hybrid N-glycan synthesis pathway
Drugs		Copper	None
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)	None
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Schizophrenia ( 25056061 29483656 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Appendicular lean mass ( 33097823 ) General cognitive ability ( 29844566 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392 ) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG disialylation phenotypes (multivariate analysis) ( 28878392 ) IgG fucosylation phenotypes (multivariate analysis) ( 28878392 ) IgG galactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG glycosylation ( 23382691 ) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391 ) IgG sialylation phenotypes (multivariate analysis) ( 28878392 ) Post bronchodilator FEV1 ( 26634245 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Schizophrenia ( 29483656 ) Sleep duration (short sleep) ( 30846698 )
Novel Interactors		6 novel interactors: CASP6 GLI2 KCTD10 MGAT3 MOB4 SF3B1	1 novel interactors: HSPD1
Interacting Genes		58 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CFTR CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT FNDC3B H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 OGT PDE4B PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG	1 interacting genes: UBAC1
Entrez ID		3329	4248
HPRD ID		00318	07058
Ensembl ID		ENSG00000144381	ENSG00000128268
Uniprot IDs		A0A024R3X4 P10809	Q09327
PDB IDs		4PJ1 6HT7 6MRC 6MRD 7AZP 7L7S 8G7J 8G7K 8G7L 8G7M 8G7N 8G7O 8U39	Not available
GO Terms Enriched among Interactors		Protein-folding Chaperone Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Signaling Cytosol Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Signal Transduction Regulation Of Proteolysis Regulation Of Calcium-mediated Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Signaling Identical Protein Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-2 Production Protein Heterodimerization Activity Regulation Of Protein Localization Glutamatergic Synapse Response To Stress Regulation Of Cytokine Production Fibroblast Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Proteolysis Regulation Of Reactive Oxygen Species Metabolic Process Integrin Alpha3-beta1 Complex Membrane Raft Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Neuron Projection Organization Regulation Of Programmed Cell Death Response To Yeast Cognition Regulation Of Cellular Localization Keratin Filament Regulation Of Multicellular Organismal Process	Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Protein Maturation Lipopolysaccharide Receptor Complex Migrasome Coated Vesicle Protein Import Into Mitochondrial Intermembrane Space Apolipoprotein A-I Binding Cellular Response To Unfolded Protein MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interleukin-7 Adhesion Of Symbiont To Host Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Interleukin-7 Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell High-density Lipoprotein Particle Binding Sperm Plasma Membrane Apolipoprotein Binding Negative Regulation Of Execution Phase Of Apoptosis 'de Novo' Protein Folding Cysteine-type Endopeptidase Activator Activity DNA Replication Origin Binding Proteasome Binding Positive Regulation Of Execution Phase Of Apoptosis Chaperone-mediated Protein Complex Assembly Isotype Switching Positive Regulation Of Macrophage Activation Regulation Of Response To Tumor Cell Positive Regulation Of Interferon-alpha Production Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Topologically Incorrect Protein Protein Refolding Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Recombination Of Immunoglobulin Gene Segments ATP-dependent Protein Folding Chaperone Lipopolysaccharide Binding Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Protein Localization To Mitochondrion Response To Cold Biological Process Involved In Interaction With Symbiont Somatic Diversification Of Immunoglobulins B Cell Proliferation Polyubiquitin Modification-dependent Protein Binding Somatic Cell DNA Recombination Toll-like Receptor Signaling Pathway Sperm Midpiece Regulation Of Macrophage Activation B Cell Activation Involved In Immune Response