HSPD1 and FHIT

Number of citations of the paper that reports this interaction (PMID 19004824)
5

Data Source:
HPRD (in vitro)

		HSPD1	FHIT
Gene Name		heat shock 60kDa protein 1 (chaperonin)	fragile histidine triad
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation	Purine Nucleotide Metabolic Process DNA Replication Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Mitochondrial protein import
Drugs			Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases
GWAS			Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Major depressive disorder ( 20125088) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553)
Protein-Protein Interactions		40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG	9 interactors: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I
Entrez ID		3329	2272
HPRD ID		00318	03096
Ensembl ID		ENSG00000144381	ENSG00000189283
Uniprot IDs		P10809	A8K1A9 P49789 Q45QG9
PDB IDs			1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound	Positive Regulation Of Cytokine Production Positive Regulation Of Protein Complex Assembly Regulation Of Cytokine Production Viral Process Regulation Of Cell Adhesion Bone Resorption Osteoclast Differentiation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Activation Positive Regulation Of Cellular Component Biogenesis Response To Cadmium Ion Bone Remodeling Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Complex Assembly Cellular Protein Complex Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Interleukin-12 Production Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Apoptotic Process Negative Regulation Of Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lymphocyte Activation Programmed Cell Death Execution Phase Of Apoptosis Oogenesis Positive Regulation Of Type I Interferon Production Protein Complex Assembly Positive Regulation Of Organelle Organization B Cell Cytokine Production Isotype Switching To IgG Isotypes Positive Regulation Of SUMO Transferase Activity Cell Death Death Adherens Junction Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Activation Response To Inorganic Substance Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Female Gamete Generation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Progesterone Stimulus
Tagcloud ?		5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Difference) ?		5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1
Tagcloud (Intersection) ?