HSPD1 and SAMD3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		HSPD1	SAMD3
Gene Name		heat shock 60kDa protein 1 (chaperonin)	sterile alpha motif domain containing 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Coated Pit Cell Surface Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Coated Vesicle Secretory Granule Protein Complex Lipopolysaccharide Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding Chaperone Binding	Protein Binding
	Biological Process	B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Viral Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation
Pathways		Mitochondrial protein import
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		40 interactors: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FHIT HIST2H2BE HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 NOTCH2NL NR3C1 PLG PPP2R1A PPP2R1B PRKACA PRNP RASA1 RGS20 SAMD3 SIRT3 SUMO4 TLR1 TMCC2 YWHAG	7 interactors: AKAP9 C6orf165 FANCG HSPD1 KDM1A LMO3 PRMT1
Entrez ID		3329	154075
HPRD ID		00318	11530
Ensembl ID		ENSG00000144381	ENSG00000164483
Uniprot IDs		P10809	B4DY20 J3KQK4 Q8N6K7
PDB IDs
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Cell Death Regulation Of Cell Death Death Apoptotic Process Positive Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Response To Organic Substance Negative Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Response To Stimulus Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Cellular Protein Metabolic Process Cell Communication Signal Transduction Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Negative Regulation Of Protein Phosphorylation Regulation Of Proteolysis Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Intracellular Signal Transduction Cell Differentiation Cell Cycle Process Negative Regulation Of Phosphorylation Response To Stress Mitotic Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Cell Cycle Anatomical Structure Development Regulation Of Cell Adhesion Positive Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Anatomical Structure Morphogenesis Positive Regulation Of Neuron Death Regulation Of Neuron Death Response To Organic Cyclic Compound	Regulation Of Megakaryocyte Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Glucocorticoid Receptor Signaling Pathway B Cell Cytokine Production Isotype Switching To IgG Isotypes Regulation Of Primitive Erythrocyte Differentiation Cell Development Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Myeloid Cell Differentiation System Development Negative Regulation Of Megakaryocyte Differentiation Gonad Development Development Of Primary Sexual Characteristics Multicellular Organismal Development Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Anatomical Structure Development Positive Regulation Of Immune Response To Tumor Cell Sex Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Hormone Biosynthetic Process Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Macrophage Activation Peptidyl-arginine N-methylation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Developmental Process Histone H4-R3 Methylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Chaperone-mediated Protein Complex Assembly Cytokine Production Involved In Immune Response Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Histone Modification Granulocyte Differentiation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Potassium Ion Transmembrane Transport Histone Arginine Methylation Positive Regulation Of Interferon-alpha Production Peptidyl-arginine Methylation Negative Regulation Of Histone Methylation Regulation Of Cell Differentiation
Tagcloud ?		5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1	adjacent androgen androgens antagonistic antagonistically ar btg1 cdca7l cdk6 chip confirming depends find htgp immunoprecipitation mapped position prostate proved publicly ra rar rare responsive restricted retinoic seq tgm4 transactivation
Tagcloud (Difference) ?		5d achieved complicated contributed dimerization earliest endogenous enhanced facilitated heat hsp60 ifn ikkepsilon induction interacted interacting interferon irf3 knockdown mavs mda mock phosphorylated progress protective rig sev shock tbk1	adjacent androgen androgens antagonistic antagonistically ar btg1 cdca7l cdk6 chip confirming depends find htgp immunoprecipitation mapped position prostate proved publicly ra rar rare responsive restricted retinoic seq tgm4 transactivation
Tagcloud (Intersection) ?