HSPD1 and SUPT6H

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		HSPD1	SUPT6H
Description		heat shock protein family D (Hsp60) member 1	SPT6 homolog, histone chaperone and transcription elongation factor
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Coated Vesicle Secretory Granule Protein-containing Complex Intracellular Membrane-bounded Organelle Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece Sperm Plasma Membrane Migrasome	Nucleus Nucleoplasm Transcription Elongation Factor Complex
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Protein-folding Chaperone Binding Cysteine-type Endopeptidase Activator Activity ATP-dependent Protein Folding Chaperone	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding
	Biological Process	Positive Regulation Of Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Folding 'de Novo' Protein Folding Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Positive Regulation Of Interferon-alpha Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Mitochondrial Unfolded Protein Response Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation Biological Process Involved In Interaction With Symbiont Cellular Response To Interleukin-7 Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis	Blastocyst Formation Nucleobase-containing Compound Metabolic Process Transcription Elongation By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Transcription Elongation By RNA Polymerase II Nucleosome Organization Regulation Of Isotype Switching MRNA Transport Regulation Of Muscle Cell Differentiation Transcription Elongation-coupled Chromatin Remodeling
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs		Copper
Diseases		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Pulse pressure ( 30578418)
Interacting Genes		58 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CFTR CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT FNDC3B H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 OGT PDE4B PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG	15 interacting genes: AKT1 CSNK2A1 DNAJB6 EGFR ERBB2 ERCC6 GAB1 HSP90B1 HSPA9 HSPD1 IWS1 MCPH1 RNF10 TCEA1 TSC2
Entrez ID		3329	6830
HPRD ID		00318	03211
Ensembl ID		ENSG00000144381	ENSG00000109111
Uniprot IDs		A0A024R3X4 P10809	Q7KZ85
PDB IDs		4PJ1 6HT7 6MRC 6MRD 7AZP 7L7S 8G7J 8G7K 8G7L 8G7M 8G7N 8G7O 8U39	6GME 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 8OEU 8OEV 8OF0 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Protein-folding Chaperone Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Signaling Cytosol Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Signal Transduction Regulation Of Proteolysis Regulation Of Calcium-mediated Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Signaling Identical Protein Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-2 Production Protein Heterodimerization Activity Regulation Of Protein Localization Glutamatergic Synapse Response To Stress Regulation Of Cytokine Production Fibroblast Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Proteolysis Regulation Of Reactive Oxygen Species Metabolic Process Integrin Alpha3-beta1 Complex Membrane Raft Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Neuron Projection Organization Regulation Of Programmed Cell Death Response To Yeast Cognition Regulation Of Cellular Localization Keratin Filament Regulation Of Multicellular Organismal Process	Protein Localization To Organelle Epidermal Growth Factor Receptor Signaling Pathway Intracellular Protein Localization ERBB Signaling Pathway Protein Folding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Unfolded Protein Binding Negative Regulation Of Apoptotic Process ATP-dependent Protein Folding Chaperone Negative Regulation Of Programmed Cell Death ATP Binding Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Cell Growth Response To Epidermal Growth Factor Cellular Localization Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Folding Chaperone ERBB2-EGFR Signaling Pathway Sperm Plasma Membrane Nucleotide Binding Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Double-strand Break Repair Via Classical Nonhomologous End Joining Establishment Of Protein Localization Positive Regulation Of Phosphorylation Positive Regulation Of Growth Anoikis Response To UV-A Nuclear Transport Nucleocytoplasmic Transport Calcium Import Into The Mitochondrion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Stress Intracellular Protein Transport Protein Tyrosine Kinase Activator Activity Regulation Of Apoptotic Process Regulation Of Translational Initiation Regulation Of RNA Metabolic Process Regulation Of Programmed Cell Death Mitochondrial Calcium Ion Transmembrane Transport Positive Regulation Of Phosphate Metabolic Process Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Regulation Of Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Regulation Of Cell Cycle ERBB2 Signaling Pathway Protein Transport
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