ULK1 and SQSTM1

Number of citations of the paper that reports this interaction (PMID 25040165)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		ULK1	SQSTM1
Gene Name		unc-51 like autophagy activating kinase 1	sequestosome 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Cytosol Cytoplasmic Vesicle Membrane Pre-autophagosomal Structure Membrane ATG1/UKL1 Signaling Complex Neuron Projection Neuronal Cell Body ULK1-ATG13-FIP200 Complex Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Pre-autophagosomal Structure Membrane Extrinsic Component Of Autophagic Vacuole Membrane	Pre-autophagosomal Structure Cytoplasmic MRNA Processing Body Nucleoplasm Cytoplasm Lysosome Late Endosome Autophagic Vacuole Endoplasmic Reticulum Cytosol Inclusion Body Aggresome PML Body Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Rab GTPase Binding Protein Kinase Binding Protein Complex Binding	Protein Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding K63-linked Polyubiquitin Binding
	Biological Process	Autophagic Vacuole Assembly Protein Phosphorylation Ras Protein Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Cerebellar Granule Cell Differentiation Radial Glia Guided Migration Of Cerebellar Granule Cell Neuron Projection Regeneration Neuron Projection Development Receptor Internalization Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Positive Regulation Of Protein Phosphorylation Immune System Process Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Protein Localization Endosomal Transport Macroautophagy Positive Regulation Of Macroautophagy Cell Differentiation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Protein Heterooligomerization Apoptotic Signaling Pathway
Pathways			Signaling by Interleukins Signalling by NGF NF-kB is activated and signals survival p75NTR recruits signalling complexes Cell death signalling via NRAGE, NRIF and NADE NRIF signals cell death from the nucleus p75NTR signals via NF-kB Cytokine Signaling in Immune system Interleukin-1 signaling p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: EXOC8 GABARAP GABARAPL2 MBP PPP1CA SDCBP SESN2 SQSTM1 SYNGAP1	74 interactors: ATXN3 BCL2 BMPR1B BPTF CALM1 CAMK2A CCNB1 CDC37 CDK1 CSNK2A1 DAZAP2 EEF1D EGLN3 FKBP4 GABARAPL1 GABARAPL2 GABRR1 GABRR2 GEMIN4 GRB14 GRIA1 GRIA2 GRIA3 IRAK1 KCNAB2 KEAP1 LCK LINC00341 MALT1 MAP1LC3A MAP1LC3B MAP2K5 MAP3K3 MAPK14 MBP MEIS2 MLH1 NBR1 NCOR1 NR2F2 NTRK1 NTRK2 NTRK3 OPTN PAWR PIK3CA PPHLN1 PRKCI PRKCZ RAD23A RELN RIPK1 RPL37 SMAD1 SMAD2 SMAD3 SMAD4 SMURF1 SNCA STXBP1 TGFBR1 TKT TOE1 TP53 TRAF6 TRIM55 TRIM63 TTN UBA52 UBB UBC ULK1 ULK2 YWHAZ
Entrez ID		8408	8878
HPRD ID		11933	03319
Ensembl ID		ENSG00000177169	ENSG00000161011
Uniprot IDs		O75385	Q13501
PDB IDs			1Q02 2JY7 2JY8 2K0B 2KNV
Enriched GO Terms of Interacting Partners?		Membrane Organization Autophagy Macroautophagy Response To External Stimulus Cellular Response To Starvation Protein Localization Nucleophagy Cellular Response To Nutrient Levels Response To Starvation Mitochondrion Degradation Cellular Response To Extracellular Stimulus Cellular Localization Cell Communication Organelle Disassembly Autophagic Vacuole Assembly Negative Regulation Of Axonogenesis Catabolic Process Cellular Component Assembly Mitochondrion Organization Exocyst Assembly Establishment Of Localization In Cell Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Cell Morphogenesis Involved In Differentiation Vacuole Organization Regulation Of Glucose Metabolic Process Negative Regulation Of Neuron Projection Development Regulation Of Phosphorylation Signaling Cellular Protein Localization Membrane Fusion Defense Response To Nematode Synaptic Transmission Protein Transport Negative Regulation Of Cell Projection Organization Response To Stimulus Cellular Lipid Catabolic Process Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Axonogenesis Intracellular Transport Exocyst Localization Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Neuron Differentiation Response To Nematode Cellular Response To Stimulus Ras Protein Signal Transduction	Cell Communication Response To Growth Factor Cellular Response To Growth Factor Stimulus Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Kinase Activity Phosphorylation Cellular Response To Organic Substance Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Kinase Activity Regulation Of Cell Death Negative Regulation Of Cell Death Response To Organic Substance Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Protein Phosphorylation Activation Of Protein Kinase Activity Membrane Organization Neurotrophin TRK Receptor Signaling Pathway Cellular Component Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Cellular Response To Stress
Tagcloud ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1
Tagcloud (Difference) ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 warranted wnt1
Tagcloud (Intersection) ?