ULK1 and EXOC8

Number of citations of the paper that reports this interaction (PMID 21241894)
45

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		ULK1	EXOC8
Gene Name		unc-51 like autophagy activating kinase 1	exocyst complex component 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Cytosol Cytoplasmic Vesicle Membrane Pre-autophagosomal Structure Membrane ATG1/UKL1 Signaling Complex Neuron Projection Neuronal Cell Body ULK1-ATG13-FIP200 Complex Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Pre-autophagosomal Structure Membrane Extrinsic Component Of Autophagic Vacuole Membrane	Exocyst Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Growth Cone
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Rab GTPase Binding Protein Kinase Binding Protein Complex Binding	Protein Binding Ral GTPase Binding
	Biological Process	Autophagic Vacuole Assembly Protein Phosphorylation Ras Protein Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Cerebellar Granule Cell Differentiation Radial Glia Guided Migration Of Cerebellar Granule Cell Neuron Projection Regeneration Neuron Projection Development Receptor Internalization Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Exocyst Assembly Organelle Organization Endosome Organization Protein Transport Extracellular Matrix Disassembly Cellular Protein Metabolic Process Exocyst Localization Membrane Organization
Pathways			Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: EXOC8 GABARAP GABARAPL2 MBP PPP1CA SDCBP SESN2 SQSTM1 SYNGAP1	20 interactors: BLOC1S6 CCDC85B CEP57L1 EFHC2 EXOC2 HGS IKZF3 KRT15 KRT18 KRT19 KRT20 KRT31 LNX1 MBIP PCM1 RAB3IL1 RALA TADA2A ULK1 USHBP1
Entrez ID		8408	149371
HPRD ID		11933	09943
Ensembl ID		ENSG00000177169	ENSG00000116903
Uniprot IDs		O75385	Q8IYI6
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Organization Autophagy Macroautophagy Response To External Stimulus Cellular Response To Starvation Protein Localization Nucleophagy Cellular Response To Nutrient Levels Response To Starvation Mitochondrion Degradation Cellular Response To Extracellular Stimulus Cellular Localization Cell Communication Organelle Disassembly Autophagic Vacuole Assembly Negative Regulation Of Axonogenesis Catabolic Process Cellular Component Assembly Mitochondrion Organization Exocyst Assembly Establishment Of Localization In Cell Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Cell Morphogenesis Involved In Differentiation Vacuole Organization Regulation Of Glucose Metabolic Process Negative Regulation Of Neuron Projection Development Regulation Of Phosphorylation Signaling Cellular Protein Localization Membrane Fusion Defense Response To Nematode Synaptic Transmission Protein Transport Negative Regulation Of Cell Projection Organization Response To Stimulus Cellular Lipid Catabolic Process Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Axonogenesis Intracellular Transport Exocyst Localization Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Neuron Differentiation Response To Nematode Cellular Response To Stimulus Ras Protein Signal Transduction	Organelle Organization Protein Localization Post-Golgi Vesicle-mediated Transport Cytoskeleton Organization Golgi To Plasma Membrane Transport Membrane Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Microtubule Anchoring Histone H3 Acetylation Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Golgi Vesicle Transport Cellular Localization Cytoplasmic Transport Radial Glia Guided Migration Of Cerebellar Granule Cell Exocytosis Establishment Of Localization In Cell Membrane Raft Localization Protein Transport Histone Acetylation Vesicle-mediated Transport Establishment Of Protein Localization Internal Peptidyl-lysine Acetylation Regulation Of Tubulin Deacetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Intracellular Transport Maintenance Of Protein Location In Cell Intraciliary Transport Involved In Cilium Morphogenesis Secretion Of Lysosomal Enzymes Microtubule-based Transport Protein Acetylation Maintenance Of Protein Location Regulation Of Cell Differentiation Cytoskeleton-dependent Intracellular Transport Maintenance Of Location In Cell Organelle Assembly Negative Regulation Of Collateral Sprouting
Tagcloud ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite
Tagcloud (Difference) ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite
Tagcloud (Intersection) ?