ULK1 and GABARAP

Number of citations of the paper that reports this interaction (PMID 11146101)
34

Data Source:
BioGRID (unspecified method)
HPRD (two hybrid, in vitro, in vivo)

		ULK1	GABARAP
Gene Name		unc-51 like autophagy activating kinase 1	GABA(A) receptor-associated protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Autophagic Vacuole Cytosol Cytoplasmic Vesicle Membrane Pre-autophagosomal Structure Membrane ATG1/UKL1 Signaling Complex Neuron Projection Neuronal Cell Body ULK1-ATG13-FIP200 Complex Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Pre-autophagosomal Structure Membrane Extrinsic Component Of Autophagic Vacuole Membrane	Golgi Membrane Pre-autophagosomal Structure Autophagic Vacuole Membrane Lysosome Autophagic Vacuole Smooth Endoplasmic Reticulum Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Actin Cytoskeleton Extrinsic Component Of Membrane Cytoplasmic Vesicle Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Rab GTPase Binding Protein Kinase Binding Protein Complex Binding	Protein Binding Microtubule Binding Beta-tubulin Binding GABA Receptor Binding
	Biological Process	Autophagic Vacuole Assembly Protein Phosphorylation Ras Protein Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Cerebellar Granule Cell Differentiation Radial Glia Guided Migration Of Cerebellar Granule Cell Neuron Projection Regeneration Neuron Projection Development Receptor Internalization Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Autophagic Vacuole Assembly Microtubule Cytoskeleton Organization Mitochondrion Degradation Protein Targeting Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Nucleophagy Membrane Fusion
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: EXOC8 GABARAP GABARAPL2 MBP PPP1CA SDCBP SESN2 SQSTM1 SYNGAP1	29 interactors: AES ATG101 ATG13 ATG3 ATG4B ATG7 DMPK DVL2 GABRG1 GABRG2 GABRG3 GPHN HDAC5 MAPK15 MLH1 MPC1 NSF PGS1 PKP4 RB1CC1 SRPK1 SRPK2 TAX1BP1 TBC1D25 TFRC TUBB3 ULK1 ULK2 VPS28
Entrez ID		8408	11337
HPRD ID		11933	05496
Ensembl ID		ENSG00000177169
Uniprot IDs		O75385	O95166 Q6IAW1
PDB IDs			1GNU 1KLV 1KM7 1KOT 3D32 3DOW
Enriched GO Terms of Interacting Partners?		Membrane Organization Autophagy Macroautophagy Response To External Stimulus Cellular Response To Starvation Protein Localization Nucleophagy Cellular Response To Nutrient Levels Response To Starvation Mitochondrion Degradation Cellular Response To Extracellular Stimulus Cellular Localization Cell Communication Organelle Disassembly Autophagic Vacuole Assembly Negative Regulation Of Axonogenesis Catabolic Process Cellular Component Assembly Mitochondrion Organization Exocyst Assembly Establishment Of Localization In Cell Response To Nutrient Levels Response To Extracellular Stimulus Negative Regulation Of Cell Morphogenesis Involved In Differentiation Vacuole Organization Regulation Of Glucose Metabolic Process Negative Regulation Of Neuron Projection Development Regulation Of Phosphorylation Signaling Cellular Protein Localization Membrane Fusion Defense Response To Nematode Synaptic Transmission Protein Transport Negative Regulation Of Cell Projection Organization Response To Stimulus Cellular Lipid Catabolic Process Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Regulation Of Axonogenesis Intracellular Transport Exocyst Localization Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Neuron Differentiation Response To Nematode Cellular Response To Stimulus Ras Protein Signal Transduction	Autophagic Vacuole Assembly Autophagy Macroautophagy Cellular Response To Extracellular Stimulus Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Vacuole Organization Response To Extracellular Stimulus Response To Nutrient Levels Organelle Assembly Regulation Of Autophagy Cell Communication Cellular Component Assembly Nucleophagy Catabolic Process Organelle Organization Mitochondrion Degradation Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Of Autophagy Organelle Disassembly Cellular Response To Stimulus Negative Regulation Of Collateral Sprouting Response To Stimulus Response To External Stimulus Cellular Response To Stress Membrane Organization Response To Stress Positive Regulation Of Macroautophagy Cellular Process Cellular Response To Nitrogen Starvation Cellular Metabolic Process Protein Localization Positive Regulation Of Viral Genome Replication Chloride Transmembrane Transport Nucleus Organization C-terminal Protein Lipidation Chloride Transport Regulation Of Cell Size Regulation Of Metabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Signaling Protein Localization To Membrane Axon Extension Positive Regulation Of Metabolic Process Anion Transmembrane Transport Glycine Receptor Clustering Nuclear Speck Organization Regulation Of Autophagic Vacuole Maturation
Tagcloud ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		antiretroviral antiviral ascribed assemble atg8 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trim trim5 trim5alpha trims tripartite	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagosome autophagosomes bak1 bcl2l11 cdkn1a cdkn1b chloroquine colocalization dysfunctional henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?		autophagic autophagy becn1