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SQSTM1 and EEF1D
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
SQSTM1
EEF1D
Gene Name
sequestosome 1
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Pre-autophagosomal Structure
Cytoplasmic MRNA Processing Body
Nucleoplasm
Cytoplasm
Lysosome
Late Endosome
Autophagic Vacuole
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Cytoplasmic Vesicle
Extracellular Vesicular Exosome
Nucleus
Nucleolus
Cytoplasm
Cytosol
Eukaryotic Translation Elongation Factor 1 Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
K63-linked Polyubiquitin Binding
DNA Binding
Translation Elongation Factor Activity
Signal Transducer Activity
Protein Binding
Translation Factor Activity, Nucleic Acid Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Immune System Process
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Response To Stress
Protein Localization
Endosomal Transport
Macroautophagy
Positive Regulation Of Macroautophagy
Cell Differentiation
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Ras Protein Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Protein Heterooligomerization
Apoptotic Signaling Pathway
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Translation
Translational Elongation
Signal Transduction
Gene Expression
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Protein Metabolic Process
Pathways
Signaling by Interleukins
Signalling by NGF
NF-kB is activated and signals survival
p75NTR recruits signalling complexes
Cell death signalling via NRAGE, NRIF and NADE
NRIF signals cell death from the nucleus
p75NTR signals via NF-kB
Cytokine Signaling in Immune system
Interleukin-1 signaling
p75 NTR receptor-mediated signalling
Translation
Eukaryotic Translation Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions
74 interactors:
ATXN3
BCL2
BMPR1B
BPTF
CALM1
CAMK2A
CCNB1
CDC37
CDK1
CSNK2A1
DAZAP2
EEF1D
EGLN3
FKBP4
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
IRAK1
KCNAB2
KEAP1
LCK
LINC00341
MALT1
MAP1LC3A
MAP1LC3B
MAP2K5
MAP3K3
MAPK14
MBP
MEIS2
MLH1
NBR1
NCOR1
NR2F2
NTRK1
NTRK2
NTRK3
OPTN
PAWR
PIK3CA
PPHLN1
PRKCI
PRKCZ
RAD23A
RELN
RIPK1
RPL37
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TGFBR1
TKT
TOE1
TP53
TRAF6
TRIM55
TRIM63
TTN
UBA52
UBB
UBC
ULK1
ULK2
YWHAZ
33 interactors:
ARHGAP21
ASCC2
ATG7
CAMSAP2
CD48
CDK1
CRMP1
CSNK2A1
CTBP1
CTBP2
ECH1
EEF1G
EPRS
ERP27
FOS
FRA10AC1
GARS
HEXDC
KARS
KTN1
MAP1B
NR2F1
POT1
PRKCA
RELA
RPS6KA1
SIAH1
SIAH2
SQSTM1
TERF1
TINF2
TPT1
VARS
Entrez ID
8878
1936
HPRD ID
03319
00560
Ensembl ID
ENSG00000161011
ENSG00000104529
Uniprot IDs
Q13501
B2RAR6
D3DWK1
P29692
PDB IDs
1Q02
2JY7
2JY8
2K0B
2KNV
Enriched GO Terms of Interacting Partners
?
Cell Communication
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Cellular Response To Stimulus
Response To Stimulus
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Phosphorylation
Response To Stress
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Signaling
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Protein Kinase Activity
Phosphorylation
Cellular Response To Organic Substance
Regulation Of Kinase Activity
Positive Regulation Of Protein Kinase Activity
Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Transferase Activity
Positive Regulation Of Kinase Activity
Regulation Of Cell Death
Negative Regulation Of Cell Death
Response To Organic Substance
Regulation Of Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Cellular Metabolic Process
Negative Regulation Of Programmed Cell Death
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Metabolic Process
Protein Phosphorylation
Activation Of Protein Kinase Activity
Membrane Organization
Neurotrophin TRK Receptor Signaling Pathway
Cellular Component Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Catalytic Activity
Cell Surface Receptor Signaling Pathway
Cellular Response To Stress
Negative Regulation Of Chromosome Organization
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Protein Metabolic Process
Movement Of Cell Or Subcellular Component
Response To External Stimulus
Negative Regulation Of Telomere Maintenance
Regulation Of Chromosome Organization
Axonogenesis
Regulation Of Telomere Maintenance Via Telomerase
Axon Development
Negative Regulation Of Cellular Protein Metabolic Process
Cell Morphogenesis Involved In Neuron Differentiation
Toll-like Receptor 5 Signaling Pathway
Negative Regulation Of Cellular Metabolic Process
Toll-like Receptor 10 Signaling Pathway
Cell Differentiation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Apoptotic Process
Neuron Projection Morphogenesis
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Regulation Of Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
MyD88-independent Toll-like Receptor Signaling Pathway
Diadenosine Tetraphosphate Biosynthetic Process
Regulation Of Telomere Maintenance
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cell Death
Cellular Macromolecule Biosynthetic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Viral Genome Replication
Cell Morphogenesis Involved In Differentiation
Negative Regulation Of Cell Death
Macromolecule Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Schwann Cell Differentiation
Neuron Projection Development
Neurotrophin TRK Receptor Signaling Pathway
Cell Projection Morphogenesis
Nucleobase-containing Compound Metabolic Process
Axon Guidance
Chemotaxis
Neurotrophin Signaling Pathway
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Histone H4 Acetylation
Tagcloud
?
aldh1a1
anxa1
bcar1
cldn1
crmp1
endpoint
folr1
foxm1
il12rb2
il7r
inconclusive
kiaa1524
lox
mcm7
mta1
mtdh
ncoa3
ndrg2
nedd9
nes
overview
pbk
ppm1d
principally
prognostication
qualifying
slc7a5
warranted
wnt1
Tagcloud (Difference)
?
aldh1a1
anxa1
bcar1
cldn1
crmp1
endpoint
folr1
foxm1
il12rb2
il7r
inconclusive
kiaa1524
lox
mcm7
mta1
mtdh
ncoa3
ndrg2
nedd9
nes
overview
pbk
ppm1d
principally
prognostication
qualifying
slc7a5
warranted
wnt1
Tagcloud (Intersection)
?