PLEKHN1 and RFX6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLEKHN1	RFX6
Gene Name		pleckstrin homology domain containing, family N member 1	regulatory factor X, 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Nucleus
	Molecular Function		RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process		Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Pancreatic D Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Pancreatic Epsilon Cell Differentiation
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 20676098)
Protein-Protein Interactions		10 interactors: LPXN LZTS2 REL RFX6 SPERT TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27	25 interactors: AES ARNT2 CATSPER1 CCNK CYFIP1 DGCR6 DTX2 ESR2 FHL3 FRS3 KIF1A LMO3 NEDD9 PITX1 PLEKHN1 PRKAA1 PRKAA2 RFX2 RFX3 RIPK3 SNRPB SNRPC SS18L1 STK16 VPS37C
Entrez ID		84069	222546
HPRD ID		13190	11490
Ensembl ID		ENSG00000187583	ENSG00000185002
Uniprot IDs		Q494U1	Q8HWS3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Protein Localization Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Component Assembly Regulation Of Protein Secretion Protein Complex Assembly Regulation Of Cellular Localization Regulation Of Gene Expression Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Pancreas Development Signal Transduction Transcription, DNA-templated Negative Regulation Of Interleukin-2 Secretion Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cytokine Production RNA Biosynthetic Process Signaling Cell Communication Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Cytokine Production Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Transport Regulation Of Secretion Maintenance Of DNA Repeat Elements Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Regulation Of Cellular Process Negative Regulation Of Calcium Ion Import Negative Regulation Of B Cell Receptor Signaling Pathway Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Insulin Secretion Embryonic Genitalia Morphogenesis Cellular Response To Stimulus Glucose Homeostasis Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Energy Homeostasis Cellular Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Fatty Acid Homeostasis Transcription From RNA Polymerase II Promoter Epithelial Cell Maturation Nitrogen Compound Metabolic Process Biosynthetic Process Histone-serine Phosphorylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Regulation Of Glycolytic Process Negative Regulation Of TOR Signaling Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Spliceosomal SnRNP Assembly Histone Phosphorylation Multicellular Organismal Development Sterol Biosynthetic Process Anion Homeostasis Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucosylceramide Biosynthetic Process Cold Acclimation Cellular Response To Extracellular Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of TOR Signaling Cellular Component Assembly Type B Pancreatic Cell Maturation Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Necroptotic Process Positive Regulation Of Cellular Metabolic Process Wnt Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Branchiomeric Skeletal Muscle Development Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Tagcloud ?			779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice
Tagcloud (Difference) ?			779a agenesis allelic annular atresia awaiting bi biliary cholestatic clues diarrhea duodenal enteroendocrine exome exploratory gallbladder hypoplasia intolerance jaundice jejunal k260t lys260thr malrotation missense monogenic necessitated neonatal pointed splice
Tagcloud (Intersection) ?