PLEKHN1 and LPXN

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLEKHN1	LPXN
Gene Name		pleckstrin homology domain containing, family N member 1	leupaxin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function		Transcription Cofactor Activity Protein Binding Zinc Ion Binding
	Biological Process		Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640)
Protein-Protein Interactions		10 interactors: LPXN LZTS2 REL RFX6 SPERT TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27	23 interactors: HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 MAP2K7 MAPK6 NDN PHF21A PLEKHH2 PLEKHN1 POM121 PTK2 PTK2B PTPN12 RUNX1T1 SFI1 TXLNB ZNF175 ZNF426
Entrez ID		84069	9404
HPRD ID		13190	05651
Ensembl ID		ENSG00000187583	ENSG00000110031
Uniprot IDs		Q494U1	B7Z5P7 O60711
PDB IDs			1X3H
Enriched GO Terms of Interacting Partners?		Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Protein Localization Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Component Assembly Regulation Of Protein Secretion Protein Complex Assembly Regulation Of Cellular Localization Regulation Of Gene Expression Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Regulation Of Nitrogen Compound Metabolic Process Pancreas Development Signal Transduction Transcription, DNA-templated Negative Regulation Of Interleukin-2 Secretion Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cytokine Production RNA Biosynthetic Process Signaling Cell Communication Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Cytokine Production Response To Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Transport Regulation Of Secretion Maintenance Of DNA Repeat Elements Regulation Of Establishment Of Protein Localization Regulation Of Cell Death Regulation Of Cellular Process Negative Regulation Of Calcium Ion Import Negative Regulation Of B Cell Receptor Signaling Pathway Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Insulin Secretion Embryonic Genitalia Morphogenesis Cellular Response To Stimulus Glucose Homeostasis Negative Regulation Of Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Regulation Of Cellular Process RNA Biosynthetic Process Signal Complex Assembly RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression MAPK Cascade Gene Expression Transcription, DNA-templated Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Cellular Response To Organic Substance Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epithelial Cell Migration Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell-matrix Adhesion Ameboidal-type Cell Migration Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Gene Expression Positive Regulation Of Kinase Activity Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Positive Regulation Of MAP Kinase Activity Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Response To Organic Substance Regulation Of Phosphatidylinositol 3-kinase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Abducens Nerve Formation Optokinetic Behavior Hsp90 Deacetylation Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Cell-matrix Adhesion
Tagcloud ?			7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5
Tagcloud (Difference) ?			7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5
Tagcloud (Intersection) ?