PLEKHN1 and PPM1J

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHN1	PPM1J
Description		pleckstrin homology domain containing N1	protein phosphatase, Mg2+/Mn2+ dependent 1J
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Membrane Mitochondrial Membrane	Mitochondrion
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidic Acid Binding Cardiolipin Binding Phosphatidylinositol Phosphate Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Apoptotic Process 3'-UTR-mediated MRNA Destabilization
Pathways
Drugs
Diseases
GWAS		Height ( 31562340) Parkinson's disease ( 26227905)	Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		42 interacting genes: ABI2 AKAP8L ARID5A ATXN1 CBY2 CYSRT1 FHL5 HOXA1 KRT31 KRT36 KRT83 KRTAP1-3 KRTAP19-6 KRTAP6-2 LPXN LZTS2 MTUS2 NBPF19 NFKBID NOTCH2NLA PDLIM7 PIH1D1 PPM1J PPP1R16B PRICKLE4 PRKAA2 REL RFX6 SAXO4 SORBS3 SSC4D TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27 TRIP6 USP54 WWOX ZC4H2 ZNF438 ZRANB1	11 interacting genes: ADORA2A CSN1S1 F2RL1 GPR37 LGALS14 PLEKHN1 PTAFR SMARCD1 SPG21 SUMO1 UBE2I
Entrez ID		84069	333926
HPRD ID		13190	15171
Ensembl ID		ENSG00000187583	ENSG00000155367
Uniprot IDs		Q494U1	Q5JR12
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament	Small Protein Activating Enzyme Binding Purinergic Nucleotide Receptor Signaling Pathway G Protein-coupled Receptor Activity Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol Vasodilation Response To 11-deoxycorticosterone Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Protein Sumoylation SUMO Conjugating Enzyme Activity Enzyme Binding Regulation Of Acetylcholine Secretion, Neurotransmission G Protein-coupled Receptor Signaling Pathway Coagulation Regulation Of Protein Transport Blood Coagulation Hemostasis Renal System Process Positive Regulation Of Acetylcholine Secretion, Neurotransmission Type 5 Metabotropic Glutamate Receptor Binding Response To Dehydroepiandrosterone Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Killing Of Cells Of Another Organism Prosaposin Receptor Activity Platelet Activating Factor Receptor Activity Inositol Trisphosphate Biosynthetic Process RING-like Zinc Finger Domain Binding SUMO Ligase Complex HLH Domain Binding PML Body Nuclear Pore Protein Localization To Nuclear Pore Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Protein Transport
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