PLEKHN1 and PPP1R16B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHN1	PPP1R16B
Description		pleckstrin homology domain containing N1	protein phosphatase 1 regulatory subunit 16B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Membrane Mitochondrial Membrane	Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidic Acid Binding Cardiolipin Binding Phosphatidylinositol Phosphate Binding	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Apoptotic Process 3'-UTR-mediated MRNA Destabilization	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Endothelial Barrier Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways
Drugs
Diseases
GWAS		Height ( 31562340) Parkinson's disease ( 26227905)	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Huntington's disease progression ( 28642124) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		42 interacting genes: ABI2 AKAP8L ARID5A ATXN1 CBY2 CYSRT1 FHL5 HOXA1 KRT31 KRT36 KRT83 KRTAP1-3 KRTAP19-6 KRTAP6-2 LPXN LZTS2 MTUS2 NBPF19 NFKBID NOTCH2NLA PDLIM7 PIH1D1 PPM1J PPP1R16B PRICKLE4 PRKAA2 REL RFX6 SAXO4 SORBS3 SSC4D TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27 TRIP6 USP54 WWOX ZC4H2 ZNF438 ZRANB1	37 interacting genes: ATPAF2 CDCA7L CEP55 CEP70 CRX DSCAM DVL2 DVL3 FAM83A FARS2 FLYWCH1 GATA1 GFAP GOLGA2 HAPLN2 HUNK IKZF3 KCTD9 MAGOH MISP NEFL PATZ1 PHC2 PLEKHN1 RBPMS RFC5 SCNM1 SF3B4 SHC3 TACO1 TADA2A TASOR2 TFIP11 TLE5 TXN2 ZNF410 ZNF564
Entrez ID		84069	26051
HPRD ID		13190	15168
Ensembl ID		ENSG00000187583	ENSG00000101445
Uniprot IDs		Q494U1	Q96T49
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament
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