SPARCL1 and DISC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		SPARCL1	DISC1
Gene Name		SPARC-like 1 (hevin)	disrupted in schizophrenia 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	Calcium Ion Binding	Protein Binding
	Biological Process	Signal Transduction	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		5 interactors: DISC1 EGFR PRNP SKIL UBC	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		8404	27185
HPRD ID		06919	05553
Ensembl ID		ENSG00000152583	ENSG00000162946
Uniprot IDs		B4E2Z0 Q14515	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Cell Cycle Process Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Regulation Of Protein Catabolic Process Cell Cycle Homeostatic Process Regulation Of Apoptotic Process Metal Ion Homeostasis Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Death Generation Of Neurons Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Neurogenesis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ion Homeostasis Cerebral Cortex Cell Migration Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Growth Factor Telencephalon Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Forebrain Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Alkanesulfonate Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Cycle Arrest Positive Regulation Of Intracellular Signal Transduction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Positive Regulation Of Cellular Protein Catabolic Process Nervous System Development Positive Regulation Of Wnt Signaling Pathway Cerebral Cortex Development G1/S Transition Of Mitotic Cell Cycle	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 prpf19 recq5 sensitize smrp transendothelial ts tymp	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		beadchip ca125 carboplatin cdkn1b chek2 ck7 cyfra21 cytokinesis deserve exceptional fancd2 illumina krt7 lig3 mesothelioma nt5c obscure pemetrexed phosphorylase platinum pola2 pold1 prpf19 recq5 sensitize smrp transendothelial ts tymp	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?