SPARCL1 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SPARCL1	TTC3
Description		SPARC like 1	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Glutamatergic Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Regulation Of Synapse Organization Synaptic Membrane Adhesion	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Idiopathic dilated cardiomyopathy ( 29495422) Urate levels ( 31578528)	Eye color traits ( 20463881)
Interacting Genes		12 interacting genes: BTG3 DISC1 DSCR9 EGFR HUNK LCOR MYCBP2 PDGFRL PRNP RCAN1 SKIL TTC3	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		8404	7267
HPRD ID		06919	03773
Ensembl ID		ENSG00000152583	ENSG00000182670
Uniprot IDs		B7ZB68 Q14515 Q8N4S1	H7BZ57 P53804
PDB IDs		7KBU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cerebral Cortex Cell Migration Cellular Response To Estradiol Stimulus Telencephalon Cell Migration Forebrain Cell Migration Skeletal Muscle Tissue Development Learning Or Memory Cognition Intracellular Signal Transduction Identical Protein Binding Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Shc-EGFR Complex Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Synapse Organization Regulation Of Cell Projection Organization Positive Regulation Of Axonogenesis Positive Regulation Of Protein Localization To Membrane Protein-containing Complex Binding Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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