SPARCL1

Description		SPARC like 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Signal Transduction Regulation Of Synapse Organization Synaptic Membrane Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Idiopathic dilated cardiomyopathy ( 29495422) Urate levels ( 31578528)
Interacting Genes		12 interacting genes: BTG3 DISC1 DSCR9 EGFR HUNK LCOR MYCBP2 PDGFRL PRNP RCAN1 SKIL TTC3
Entrez ID		8404
HPRD ID		06919
Ensembl ID		ENSG00000152583
Uniprot IDs		B7ZB68 Q14515 Q8N4S1
PDB IDs		7KBU
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cerebral Cortex Cell Migration Cellular Response To Estradiol Stimulus Telencephalon Cell Migration Forebrain Cell Migration Skeletal Muscle Tissue Development Learning Or Memory Cognition Intracellular Signal Transduction Identical Protein Binding Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Shc-EGFR Complex Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Synapse Organization Regulation Of Cell Projection Organization Positive Regulation Of Axonogenesis Positive Regulation Of Protein Localization To Membrane Protein-containing Complex Binding Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone
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