SPARCL1 and PDGFRL

Number of citations: 0 (PubMedID 24412244)
Data Source: BioGRID (two hybrid)

		SPARCL1	PDGFRL
Name		SPARC like 1	platelet derived growth factor receptor like
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Glutamatergic Synapse	Extracellular Region
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity
	Biological Process	Signal Transduction Regulation Of Synapse Organization Synaptic Membrane Adhesion	G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	None
GWAS		Blood protein levels ( 30072576 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Urate levels ( 31578528 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Hippocampal volume in normal cognition ( 29274321 ) Placental abruption ( 29884306 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Plasma parathyroid hormone levels ( 30134803 ) Spatial memory ( 31596458 ) Sphingomyelin 24:0 levels ( 31560688 )
Novel Interactors		None recorded	1 novel interactors: PCM1
Interacting Genes		12 interacting genes: BTG3 DISC1 DSCR9 EGFR HUNK LCOR MYCBP2 PDGFRL PRNP RCAN1 SKIL TTC3	24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510
Entrez ID		8404	5157
HPRD ID		06919	05206
Ensembl ID		ENSG00000152583	ENSG00000104213
Uniprot IDs		B7ZB68 Q14515 Q8N4S1	Q15198
PDB IDs		7KBU	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Cerebral Cortex Cell Migration Cellular Response To Estradiol Stimulus Telencephalon Cell Migration Forebrain Cell Migration Skeletal Muscle Tissue Development Learning Or Memory Cognition Intracellular Signal Transduction Identical Protein Binding Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Shc-EGFR Complex Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Platelet-derived Growth Factor Beta-receptor Activity Platelet-derived Growth Factor Receptor Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Synapse Organization Regulation Of Cell Projection Organization Positive Regulation Of Axonogenesis Positive Regulation Of Protein Localization To Membrane Protein-containing Complex Binding Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Platelet Activating Factor Receptor Activity Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone	Myelination Axon Ensheathment MAPK Cascade Regulation Of Intracellular Transport Glial Cell Development Schwann Cell Development Regulation Of Cellular Localization Regulation Of Golgi Inheritance Intracellular Signaling Cassette Trachea Formation Regulation Of Intracellular Protein Transport Fructose 1,6-bisphosphate Metabolic Process ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Catalytic Activity Bergmann Glial Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of ERK1 And ERK2 Cascade Chemical Homeostasis Cytosol Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell-cell Adhesion Regulation Of Transport Regulation Of Protein Localization MAP Kinase Activity Positive Regulation Of Intracellular Protein Transport Regulation Of MiRNA Metabolic Process Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Homeostatic Process Negative Regulation Of Transport Regulation Of Protein Transport Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Protein Transport Animal Organ Formation Face Development Negative Regulation Of Cell Population Proliferation ERBB2 Signaling Pathway Intracellular Signal Transduction Gland Development Positive Regulation Of Hydrolase Activity Muscle Cell Cellular Homeostasis Regulation Of Protein Localization To Synapse Lung Morphogenesis