UBE2K and TRIM35

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2K	TRIM35
Gene Name		ubiquitin-conjugating enzyme E2K	tripartite motif containing 35
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Molecular_function Zinc Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination	Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Viral Release From Host Cell
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS
Protein-Protein Interactions		68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17	13 interactors: PAN2 TRIM11 TRIM5 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2K UBE2U UBE2W USP2 USP49
Entrez ID		3093	23087
HPRD ID		04165	15553
Ensembl ID		ENSG00000078140	ENSG00000104228
Uniprot IDs		B4DIZ2 P61086	E5RGB3 Q9UPQ4
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Response To Stress Cellular Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Negative Regulation Of Viral Release From Host Cell Immune Response Negative Regulation Of Viral Entry Into Host Cell Defense Response Regulation Of Protein Catabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Cellular Response To Stress Immune Response-regulating Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized	advance advantage blockade box coil coiled collectively consisting doi hcc hepatocellular isoform m2 onc oncogene online pkm2 publication pyruvate rbcc reprogramming september suppress suppresses tripartite tumorigenicity uses warburg y105
Tagcloud (Difference) ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 ubiquitin unanchored unrecognized	advance advantage blockade box coil coiled collectively consisting doi hcc hepatocellular isoform m2 onc oncogene online pkm2 publication pyruvate rbcc reprogramming september suppress suppresses tumorigenicity uses warburg y105
Tagcloud (Intersection) ?		tripartite