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UBE2K and MKRN3
Number of citations of the paper that reports this interaction (PMID
19549727
)
40
Data Source:
BioGRID
(two hybrid)
UBE2K
MKRN3
Gene Name
ubiquitin-conjugating enzyme E2K
makorin ring finger protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Actin Cytoskeleton
Intermediate Filament Cytoskeleton
Extracellular Vesicular Exosome
Ribonucleoprotein Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K48-linked Ubiquitination
Protein Ubiquitination
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Antigen processing: Ubiquitination & Proteasome degradation
Negative regulators of RIG-I/MDA5 signaling
Class I MHC mediated antigen processing & presentation
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
68 interactors:
AMFR
ANAPC11
BFAR
BIRC7
BIRC8
BRCA1
CASP12
CBLC
CDC6
DDI1
DDX58
DIABLO
DTX3
DTX3L
DZIP3
FZR1
HTT
ITCH
ITSN1
LRSAM1
MARCH3
MARCH7
MDM2
MID1
MIPOL1
MKRN2
MKRN3
NEDD4L
NEDD8
NFKB1
NUB1
PIAS4
PRPF40A
PRRG4
RBCK1
REL
RING1
RNF111
RNF114
RNF125
RNF138
RNF144A
RNF167
RNF2
RNF32
RNF4
RNF41
RNF5
SIAH1
TP53
TRAF7
TRAIP
TRIM2
TRIM27
TRIM3
TRIM31
TRIM34
TRIM35
TRIM39
TRIM43
TRIM5
UBA1
UBC
UBE2I
UBOX5
UHRF2
WWP2
ZDHHC17
55 interactors:
ANKRD11
BEX2
CRACR2A
ENKD1
ERCC1
FAM110A
FAM124B
FARS2
KIF1A
LRSAM1
MDM2
MDM4
MEOX2
MNAT1
MRPS6
NABP1
NDE1
PEX10
PEX5
PRPF31
PSMA1
RBM41
RNF166
RNF32
RNF7
SCNM1
SF1
SFN
TCEA2
TCHP
TFAP2A
TRIM23
TRIM31
TRIM34
TRIM5
TRIM65
TRIM8
TSG101
TTC25
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L3
UBE2N
UBE2U
UBE2V1
UBE2V2
UBE2W
Entrez ID
3093
7681
HPRD ID
04165
04836
Ensembl ID
ENSG00000078140
ENSG00000179455
Uniprot IDs
B4DIZ2
P61086
Q13064
PDB IDs
1YLA
2O25
3E46
3F92
3K9O
3K9P
Enriched GO Terms of Interacting Partners
?
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Cellular Protein Modification Process
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Cellular Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Proteolysis
Proteasomal Protein Catabolic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Cell Death
Protein K63-linked Ubiquitination
Negative Regulation Of Cellular Metabolic Process
Metabolic Process
Regulation Of Apoptotic Process
Catabolic Process
Protein Autoubiquitination
Positive Regulation Of Signal Transduction
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of RNA Biosynthetic Process
Viral Process
Neuron Apoptotic Process
Response To Stress
Negative Regulation Of Biosynthetic Process
Regulation Of Viral Release From Host Cell
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Process
Neuron Death
Regulation Of Signaling
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Cycle
Protein Polyubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Protein Modification Process
Cellular Protein Metabolic Process
Cellular Response To Stress
Catabolic Process
Cellular Response To DNA Damage Stimulus
Protein Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Metabolic Process
Response To Stress
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Ubiquitin-protein Transferase Activity
Activation Of Innate Immune Response
Positive Regulation Of Ligase Activity
Toll-like Receptor 4 Signaling Pathway
Proteolysis
Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Cellular Response To Hypoxia
Positive Regulation Of Innate Immune Response
Cellular Response To Decreased Oxygen Levels
DNA Repair
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Innate Immune Response
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cell Cycle Process
Negative Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Protein Ubiquitination
Cell Cycle
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Innate Immune Response
Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Protein Catabolic Process
Viral Process
Tagcloud
?
antiviral
attributes
breadth
chains
conjugase
cooperated
demands
e3
elicits
elusive
epsilon
hundreds
identifies
ifn
ikkepsilon
interacted
interferons
isg
isgs
k48
ligase
polyubiquitin
stat1
trim
trim6
tripartite
ubiquitin
unanchored
unrecognized
Tagcloud (Difference)
?
antiviral
attributes
breadth
chains
conjugase
cooperated
demands
e3
elicits
elusive
epsilon
hundreds
identifies
ifn
ikkepsilon
interacted
interferons
isg
isgs
k48
ligase
polyubiquitin
stat1
trim
trim6
tripartite
ubiquitin
unanchored
unrecognized
Tagcloud (Intersection)
?