UBE2K and MARCHF7

Number of citations of the paper that reports this interaction (PubMedID 37632749)
0

Data Source:
BioGRID (pull down)

		UBE2K	MARCHF7
Description		ubiquitin conjugating enzyme E2 K	membrane associated ring-CH-type finger 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Filopodium Tip	Nucleus Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity MDM2/MDM4 Family Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Regulation Of Tolerance Induction Protein Monoubiquitination Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of T Cell Proliferation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Stabilization Protein Autoubiquitination Cilium Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cilium Assembly Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Protein Autoubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		98 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 CEBPA DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF213 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM13 TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM6 TRIM63 TSN UBA1 UBA5 UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	22 interacting genes: ATG14 CTNNA3 EXOC8 HSF2BP IQCB1 MAPRE1 MAPRE3 MAPT NLRP3 PPP3CA PPP3CB RNF111 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2K UBE2M UBE2N USP7
Entrez ID		3093	64844
HPRD ID		04165	09817
Ensembl ID		ENSG00000078140	ENSG00000136536
Uniprot IDs		B3KSH4 B4DIZ2 P61086	B7Z5K0 B7ZAR7 F5H6W4 Q9H992
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7 7MYF 7MYH 7OJX
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Modification Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Transferase Activity Zinc Ion Binding Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Catabolic Process Proteolysis Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Regulation Of Signaling Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Identical Protein Binding Protein K6-linked Ubiquitination Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Innate Immune Response Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction SUMO Transferase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Polyubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination Cytosol Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Mitotic Spindle Astral Microtubule End Calmodulin-dependent Protein Phosphatase Activity Macromolecule Metabolic Process Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Protein Monoubiquitination Catabolic Process Protein Serine/threonine Phosphatase Complex Positive Regulation Of Metabolic Process Positive Regulation Of Calcium Ion Import Across Plasma Membrane Ubiquitin Protein Ligase Activity TORC1 Signaling Regulation Of Microtubule Polymerization Negative Regulation Of TORC1 Signaling Regulation Of Autophagy Positive Regulation Of Protein Modification Process Cytoplasm Regulation Of Protein Modification Process Positive Regulation Of Protein-containing Complex Assembly Protein Polymerization Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Protein Localization To Microtubule Transferase Activity TOR Signaling Regulation Of Protein-containing Complex Assembly ATP Binding Organelle Assembly Negative Regulation Of TOR Signaling Regulation Of Calcium-mediated Signaling Positive Regulation Of Protein Polyubiquitination Microtubule Organizing Center Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of TORC1 Signaling Regulation Of Microtubule Polymerization Or Depolymerization
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