UBE2K and RNF138

Number of citations of the paper that reports this interaction (PMID 16714285)
30

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		UBE2K	RNF138
Gene Name		ubiquitin-conjugating enzyme E2K	ring finger protein 138, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Zinc Ion Binding Ligase Activity Protein Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination	Wnt Signaling Pathway Protein Ubiquitination
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17	13 interactors: APP C6orf165 LEF1 LNX2 PCBP4 QKI TAF9 TCF4 TRIM8 UBE2D2 UBE2D4 UBE2K UBE2W
Entrez ID		3093	51444
HPRD ID		04165	11508
Ensembl ID		ENSG00000078140	ENSG00000134758
Uniprot IDs		B4DIZ2 P61086	Q8WVD3
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Regulation Of Protein Binding Protein K11-linked Ubiquitination Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Cellular Protein Metabolic Process Regulation Of Growth Face Morphogenesis Head Morphogenesis Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Binding Histone H3 Acetylation Response To Stress Face Development Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Body Morphogenesis Cellular Response To Stress Positive Regulation Of Gene Expression Muscle Cell Differentiation Regulation Of Viral Transcription Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Diencephalon Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway 3'-UTR-mediated MRNA Destabilization Synaptic Growth At Neuromuscular Junction Negative Regulation Of Apoptotic Process In Bone Marrow Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Forebrain Development Posttranscriptional Regulation Of Gene Expression Odontogenesis Of Dentin-containing Tooth Regulation Of Cellular Protein Metabolic Process Histone Acetylation Positive Regulation Of Cell Growth Ubiquitin-dependent Protein Catabolic Process Internal Peptidyl-lysine Acetylation Muscle Structure Development Cellular Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Neutrophil Differentiation
Tagcloud ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized	20s aggravates bag6 d139e dnajb1 ef1a foetal hsp70s map1a map1b mesencephalic microtubule multifunctional neurones neuroprotection nigra ohda opn osteopontin pleiotrophin pull rgd sgtalpha sn substantia surviving utilised y165a yth
Tagcloud (Difference) ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized	20s aggravates bag6 d139e dnajb1 ef1a foetal hsp70s map1a map1b mesencephalic microtubule multifunctional neurones neuroprotection nigra ohda opn osteopontin pleiotrophin pull rgd sgtalpha sn substantia surviving utilised y165a yth
Tagcloud (Intersection) ?