UBE2K and RLIM

Number of citations of the paper that reports this interaction (PubMedID 32416094)
0

Data Source:
BioGRID (pull down)

		UBE2K	RLIM
Description		ubiquitin conjugating enzyme E2 K	ring finger protein, LIM domain interacting
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Filopodium Tip	Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494)	Brain asymmetrical skew (horizontal) ( 33836062)
Interacting Genes		98 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 CEBPA DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF213 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM13 TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM6 TRIM63 TSN UBA1 UBA5 UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	31 interacting genes: BRF1 CDK2 CFLAR ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LMO4 LNX2 MDM2 PDLIM1 REXO1 SIN3A SMURF2 SNX17 SS18L1 STAT6 TERF1 TNFAIP3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2K
Entrez ID		3093	51132
HPRD ID		04165	02304
Ensembl ID		ENSG00000078140	ENSG00000131263
Uniprot IDs		B3KSH4 B4DIZ2 P61086	Q9NVW2
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7 7MYF 7MYH 7OJX	6W7Z 6W9A 6W9D
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Modification Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Transferase Activity Zinc Ion Binding Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Catabolic Process Proteolysis Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Regulation Of Signaling Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Identical Protein Binding Protein K6-linked Ubiquitination Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Innate Immune Response Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction SUMO Transferase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Transcription Regulator Complex Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Central Nervous System Neuron Differentiation Neuron Differentiation Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Spinal Cord Association Neuron Differentiation Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Regulation Of Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification Process Motor Neuron Axon Guidance Regulation Of Gene Expression Neuron Fate Specification
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