UBE2K and KRIT1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		UBE2K	KRIT1
Name		ubiquitin conjugating enzyme E2 K	KRIT1 ankyrin repeat containing
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Filopodium Tip	Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Anchoring Junction
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Microtubule Binding GTPase Regulator Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Endothelium Development Small GTPase-mediated Signal Transduction Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Integrin Activation Cell Redox Homeostasis Regulation Of Angiogenesis Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	None
Diseases		None	Cerebral cavernous malformation
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457 ) Platelet count ( 32888494 )	Coffee consumption ( 31046077 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 )
Novel Interactors		None recorded	1 novel interactors: CDK6
Interacting Genes		98 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CCNC CDC6 CEBPA DDI1 DIABLO DTX3 DTX3L DZIP3 EXOSC7 FZR1 HTT ITCH ITSN1 KRIT1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MEOX2 MID1 MID2 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PAX6 PIAS4 PICK1 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF138 RNF144A RNF166 RNF167 RNF182 RNF183 RNF185 RNF2 RNF213 RNF31 RNF32 RNF4 RNF41 RNF5 SDCBP SENP1 SH3RF1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM13 TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM50 TRIM6 TRIM63 TSN UBA1 UBA5 UBE2I UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384	7 interacting genes: ITGB1BP1 PLCB3 RAP1A RGS4 TIAM1 TRPV4 UBE2K
Entrez ID		3093	889
HPRD ID		04165	05020
Ensembl ID		ENSG00000078140	ENSG00000001631
Uniprot IDs		B3KSH4 B4DIZ2 P61086	A4D1F7 O00522
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7 7MYF 7MYH 7OJX	3U7D 4DX8 4DXA 4HDO 4HDQ 4JIF 4TKN 5D68 6OQ3 6OQ4 6UZK 8SU8 8T09 8T7V
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Protein Modification Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Transferase Activity Zinc Ion Binding Protein Metabolic Process Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Catabolic Process Proteolysis Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Cytoplasm Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Protein K48-linked Ubiquitination Regulation Of Signaling Regulation Of Cell Communication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Stress Identical Protein Binding Protein K6-linked Ubiquitination Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Ubiquitin Ligase Complex Innate Immune Response Regulation Of Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Suppression Of Viral Release By Host Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction SUMO Transferase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process	Signal Transduction Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex Regulation Of Cell Differentiation FBXO Family Protein Binding Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Signaling Protein Polymerization Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Calmodulin Binding Calcium Ion Transmembrane Import Into Cytosol Regulation Of Neuron Projection Development Regulation Of ERK1 And ERK2 Cascade Response To Antineoplastic Agent Anchoring Junction Negative Regulation Of Glycine Import Across Plasma Membrane Protein Kinase Binding Regulation Of Supramolecular Fiber Organization Osmosensor Activity Blood Vessel Endothelial Cell Delamination Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Kinase Binding Ruffle Positive Regulation Of Cellular Component Organization Cell-matrix Adhesion Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Dopamine Receptor Signaling Pathway Cellular Hypotonic Salinity Response Vasopressin Secretion Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell-substrate Adhesion Protein-containing Complex Assembly Positive Regulation Of Protein Kinase Activity