UBE2K and BIRC8

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2K	BIRC8
Gene Name		ubiquitin-conjugating enzyme E2K	baculoviral IAP repeat containing 8
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Actin Cytoskeleton Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Spindle Microtubule Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protease Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Scaffold Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination	Protein Ubiquitination Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Canonical Wnt Signaling Pathway Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		68 interactors: AMFR ANAPC11 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MARCH3 MARCH7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PRPF40A PRRG4 RBCK1 REL RING1 RNF111 RNF114 RNF125 RNF138 RNF144A RNF167 RNF2 RNF32 RNF4 RNF41 RNF5 SIAH1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 UBA1 UBC UBE2I UBOX5 UHRF2 WWP2 ZDHHC17	12 interactors: CASP9 MAGED1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2K UBE2N UBE2V1 UBE2W
Entrez ID		3093	112401
HPRD ID		04165	12525
Ensembl ID		ENSG00000078140	ENSG00000163098
Uniprot IDs		B4DIZ2 P61086	Q6PIA0 Q96P09
PDB IDs		1YLA 2O25 3E46 3F92 3K9O 3K9P	1XB0 1XB1
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteolysis Proteasomal Protein Catabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Death Protein K63-linked Ubiquitination Negative Regulation Of Cellular Metabolic Process Metabolic Process Regulation Of Apoptotic Process Catabolic Process Protein Autoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of RNA Biosynthetic Process Viral Process Neuron Apoptotic Process Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Viral Release From Host Cell Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Neuron Death Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Toll-like Receptor Signaling Pathway Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Stress Cellular Protein Modification Process Protein K11-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Catabolic Process Protein K63-linked Ubiquitination Protein Metabolic Process Protein Monoubiquitination Innate Immune Response Regulation Of Immune Response Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Oxygen Levels Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus
Tagcloud ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Difference) ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 trim trim6 tripartite ubiquitin unanchored unrecognized
Tagcloud (Intersection) ?