PICALM and PELI2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PICALM	PELI2
Name		phosphatidylinositol binding clathrin assembly protein	pellino E3 ubiquitin protein ligase family member 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Endomembrane System Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Cytosol
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Small GTPase Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Vesicle Cargo Loading Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Multicellular Organismal-level Iron Ion Homeostasis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Cell Surface	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Regulation Of Toll Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RND3 GTPase cycle	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
GWAS		Alzheimer's disease ( 19734902 21627779 22832961 31473137 ) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Chronic obstructive pulmonary disease ( 30804561 ) Family history of Alzheimer's disease ( 30617256 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287 ) Mean platelet volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Refractive error ( 32231278 ) Tourette syndrome ( 22889924 )	Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054 ) Body mass index (smoking years interaction) ( 23192594 ) Body mass index (ever vs never smoking interaction) ( 23192594 ) Chronic obstructive pulmonary disease-related biomarkers ( 23144326 ) End-stage kidney disease ( 31178898 ) Height ( 25133637 ) Nickel levels ( 26025379 ) Telomere length ( 21460395 )
Novel Interactors		None recorded	1 novel interactors: TIMM9
Interacting Genes		21 interacting genes: AP2A1 ATXN1 ATXN1L CASP3 CASP8 CDC42 CLTC CLTCL1 CRX DDIT3 EHD2 EPS15 FCHO1 ITSN1 OGT PELI2 PLCG1 RBPMS SMURF1 TENM1 ZC3H10	44 interacting genes: BCL10 CEP170B CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 IRS1 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MPDZ MYD88 MYO10 NEK9 NUP62 OR7D2 PCGF2 PICALM PRR36 RABEP1 RBBP8 REL RMDN3 RNF220 SEPTIN3 SP4 SRPK1 TGM2 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4 YTHDF2
Entrez ID		8301	57161
HPRD ID		04320	17835
Ensembl ID		ENSG00000073921	ENSG00000139946
Uniprot IDs		Q13492	Q9H716 Q9HAT8
PDB IDs		Not available	3EGA 3EGB
GO Terms Enriched among Interactors		Postsynaptic Endocytic Zone Clathrin-coated Pit Clathrin-coated Vesicle Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-dependent Endocytosis Receptor-mediated Endocytosis Import Into Cell Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytosol Intracellular Transport Negative Regulation Of Hyaluronan Biosynthetic Process POZ Domain Binding Endosomal Transport Cytosolic Transport Pyroptotic Inflammatory Response Response To Anesthetic Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Transport Cellular Localization Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Establishment Of Localization In Cell Death-inducing Signaling Complex Clathrin Complex Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Glutamatergic Synapse Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion AP-2 Adaptor Complex Positive Regulation Of Macromolecule Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Neuron Apoptotic Process Receptor Internalization Intracellular Protein Localization Golgi To Endosome Transport Vesicle-mediated Transport In Synapse Death Receptor Binding Positive Regulation Of Metabolic Process Protein-containing Complex Regulation Of Macromolecule Metabolic Process Endolysosome Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Transport Execution Phase Of Apoptosis Regulation Of Vesicle-mediated Transport Low-density Lipoprotein Particle Receptor Binding	Toll Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Interleukin-33-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process General Transcription Initiation Factor Binding Positive Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response-activating Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Activation Of Innate Immune Response Positive Regulation Of Defense Response Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Endolysosomal Toll-like Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Signaling Adaptor Activity Anatomical Structure Morphogenesis Regulation Of Apoptotic Signaling Pathway Response To Interleukin-1 Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Defense Response Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Response To Stress Regulation Of Cell Communication Cellular Developmental Process Regulation Of Signaling Regulation Of Gene Expression Positive Regulation Of DNA-binding Transcription Factor Activity