PICALM and PELI2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PICALM	PELI2
Gene Name		phosphatidylinositol binding clathrin assembly protein	pellino E3 ubiquitin protein ligase family member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Coated Pit Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neurofibrillary Tangle	Cytosol
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Clathrin Binding Clathrin Heavy Chain Binding Clathrin Adaptor Activity	Protein Binding Ligase Activity
	Biological Process	Protein Complex Assembly Receptor-mediated Endocytosis Axonogenesis Cell Proliferation Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Cargo Loading Into Vesicle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Iron Ion Homeostasis Clathrin-mediated Endocytosis Iron Ion Import Into Cell Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll Signaling Pathway Protein Ubiquitination Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Toll Like Receptor 7/8 (TLR7/8) Cascade Cytokine Signaling in Immune system Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Signaling by Interleukins Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Interleukin-1 signaling Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation IRAK1 recruits IKK complex Innate Immune System
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 19734902 21627779) Alzheimer's disease (late onset) ( 21460841) Tourette syndrome ( 22889924)	Body mass index (interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Telomere length ( 21460395)
Protein-Protein Interactions		10 interactors: AP2A1 CASP3 CASP8 CLTC CLTCL1 DDIT3 EHD2 ITSN1 PELI2 PLCG1	17 interactors: BCL10 CREB3L3 DEAF1 ERO1L FN1 FRYL HNRNPK IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 MYD88 PICALM SRPK1 THAP7 UBQLN4
Entrez ID		8301	57161
HPRD ID		04320	17835
Ensembl ID		ENSG00000073921	ENSG00000139946
Uniprot IDs		Q13492	Q9H716 Q9HAT8
PDB IDs			3EGA 3EGB
Enriched GO Terms of Interacting Partners?		Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Cell Morphogenesis Involved In Differentiation Cellular Localization Anatomical Structure Morphogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Phosphorus Metabolic Process Regulation Of Neuron Death Intracellular Transport Response To Organic Substance Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Intracellular Signal Transduction Signaling Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Phosphorylation Cell Communication Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Receptor-mediated Endocytosis Execution Phase Of Apoptosis Positive Regulation Of Neuron Death Negative Regulation Of Determination Of Dorsal Identity	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway JNK Cascade Regulation Of Innate Immune Response Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Defense Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Metabolic Process Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response-regulating Signaling Pathway MAPK Cascade Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Response To Stress Response To Interleukin-1 Response To Peptidoglycan Regulation Of RNA Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Smooth Muscle Cell Proliferation Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Molecule Of Bacterial Origin Interleukin-1-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cytokine Biosynthetic Process Positive Regulation Of Peptidase Activity
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Intersection) ?