PICALM and TENM1

Number of citations: 70 (PubMedID 25648896)
Data Source: BioGRID (two hybrid)

		PICALM	TENM1
Name		phosphatidylinositol binding clathrin assembly protein	teneurin transmembrane protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Endomembrane System Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytoskeleton Plasma Membrane Membrane Nuclear Matrix Nuclear Speck Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Small GTPase Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Heparin Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Vesicle Cargo Loading Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Multicellular Organismal-level Iron Ion Homeostasis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Cell Surface	Regulation Of Transcription By RNA Polymerase III Immune Response Signal Transduction Neuropeptide Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of MAP Kinase Activity Neuron Development Positive Regulation Of Filopodium Assembly Positive Regulation Of Intracellular Protein Transport
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RND3 GTPase cycle	None
GWAS		Alzheimer's disease ( 19734902 21627779 22832961 31473137 ) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 ) Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease in APOE e4+ carriers ( 25778476 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Chronic obstructive pulmonary disease ( 30804561 ) Family history of Alzheimer's disease ( 30617256 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287 ) Mean platelet volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Refractive error ( 32231278 ) Tourette syndrome ( 22889924 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: AP2A1 ATXN1 ATXN1L CASP3 CASP8 CDC42 CLTC CLTCL1 CRX DDIT3 EHD2 EPS15 FCHO1 ITSN1 OGT PELI2 PLCG1 RBPMS SMURF1 TENM1 ZC3H10	12 interacting genes: APBB1 BEX1 CSNK2B FIBP MACF1 MBD1 NUBP1 PICALM POLR2J PTPN12 RACK1 SORBS1
Entrez ID		8301	10178
HPRD ID		04320	06669
Ensembl ID		ENSG00000073921	ENSG00000009694
Uniprot IDs		Q13492	B7ZMH4 Q9UKZ4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Postsynaptic Endocytic Zone Clathrin-coated Pit Clathrin-coated Vesicle Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-dependent Endocytosis Receptor-mediated Endocytosis Import Into Cell Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytosol Intracellular Transport Negative Regulation Of Hyaluronan Biosynthetic Process POZ Domain Binding Endosomal Transport Cytosolic Transport Pyroptotic Inflammatory Response Response To Anesthetic Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Transport Cellular Localization Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Establishment Of Localization In Cell Death-inducing Signaling Complex Clathrin Complex Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Glutamatergic Synapse Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion AP-2 Adaptor Complex Positive Regulation Of Macromolecule Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Neuron Apoptotic Process Receptor Internalization Intracellular Protein Localization Golgi To Endosome Transport Vesicle-mediated Transport In Synapse Death Receptor Binding Positive Regulation Of Metabolic Process Protein-containing Complex Regulation Of Macromolecule Metabolic Process Endolysosome Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Transport Execution Phase Of Apoptosis Regulation Of Vesicle-mediated Transport Low-density Lipoprotein Particle Receptor Binding	Low-density Lipoprotein Particle Receptor Binding Nucleus Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Membrane