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PICALM and CASP8
Number of citations of the paper that reports this interaction (PubMedID
10926122
)
0
Data Source:
HPRD
(in vitro)
PICALM
CASP8
Description
phosphatidylinositol binding clathrin assembly protein
caspase 8
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Early Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Clathrin-coated Pit
Synaptic Vesicle
Cell Surface
Endomembrane System
Membrane
Clathrin Coat Of Coated Pit
Clathrin-coated Vesicle
Cytoplasmic Vesicle
Vesicle
Presynaptic Membrane
Neuronal Cell Body
Postsynaptic Membrane
Clathrin-coated Endocytic Vesicle
Perinuclear Region Of Cytoplasm
Endosome To Plasma Membrane Transport Vesicle
Neurofibrillary Tangle
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Lamellipodium
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Protein-containing Complex
Cell Projection
Cell Body
Ripoptosome
Molecular Function
SNARE Binding
Amyloid-beta Binding
Protein Binding
Phospholipid Binding
1-phosphatidylinositol Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Clathrin Binding
Small GTPase Binding
Clathrin Heavy Chain Binding
Cadherin Binding
Tau Protein Binding
Low-density Lipoprotein Particle Receptor Binding
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Ubiquitin Protein Ligase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Scaffold Protein Binding
Biological Process
Intracellular Iron Ion Homeostasis
Endocytosis
Receptor-mediated Endocytosis
Vesicle Budding From Membrane
Axonogenesis
Learning Or Memory
Negative Regulation Of Gene Expression
Synaptic Vesicle Maturation
Vesicle-mediated Transport
Endosomal Transport
Hemopoiesis
Regulation Of Endocytosis
Receptor Internalization
Regulation Of Protein Localization
Vesicle Cargo Loading
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Ras Protein Signal Transduction
Regulation Of Receptor-mediated Endocytosis
Negative Regulation Of Receptor-mediated Endocytosis
Clathrin Coat Assembly
Dendrite Morphogenesis
Multicellular Organismal-level Iron Ion Homeostasis
Protein-containing Complex Assembly
Clathrin-dependent Endocytosis
Regulation Of Vesicle Size
Membrane Bending
Amyloid-beta Clearance By Transcytosis
Regulation Of Amyloid-beta Formation
Positive Regulation Of Amyloid-beta Formation
Regulation Of Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Negative Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Protein Localization To Cell Surface
Autophagosome Assembly
Angiogenesis
Regulation Of Cytokine Production
Regulation Of Immune System Process
Proteolysis
Apoptotic Process
Heart Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Signal Transduction
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Processing
Natural Killer Cell Activation
Cell Differentiation
Macrophage Differentiation
Positive Regulation Of Cell Migration
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Beta Production
Response To Tumor Necrosis Factor
TRAIL-activated Apoptotic Signaling Pathway
T Cell Activation
B Cell Activation
Regulation Of Apoptotic Process
Chordate Embryonic Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Innate Immune Response
Response To Ethanol
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Animal Organ Development
Proteolysis Involved In Protein Catabolic Process
Protein Maturation
Negative Regulation Of Necroptotic Process
Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development
Pyroptotic Inflammatory Response
Cellular Response To Mechanical Stimulus
Response To Anesthetic
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Self Proteolysis
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of Execution Phase Of Apoptosis
Pathways
Golgi Associated Vesicle Biogenesis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
RND3 GTPase cycle
Apoptotic cleavage of cellular proteins
Caspase activation via Death Receptors in the presence of ligand
NOD1/2 Signaling Pathway
TRIF-mediated programmed cell death
Caspase-mediated cleavage of cytoskeletal proteins
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
CLEC7A/inflammasome pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
Activation, myristolyation of BID and translocation to mitochondria
Apoptotic execution phase
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Microbial modulation of RIPK1-mediated regulated necrosis
Defective RIPK1-mediated regulated necrosis
Regulation of NF-kappa B signaling
Drugs
Trichostatin A
AN-9
Bryostatin 1
Bardoxolone
Oleandrin
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Alzheimer's disease (
19734902
21627779
22832961
31473137
)
Alzheimer's disease (late onset) (
21460841
30617256
24162737
)
Alzheimer's disease (onset between ages 58 and 79) (
30979435
)
Alzheimer's disease in APOE e4+ carriers (
25778476
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Chronic obstructive pulmonary disease (
30804561
)
Family history of Alzheimer's disease (
30617256
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) (
26741287
)
Mean platelet volume (
32888494
)
Platelet count (
27863252
32888494
)
Refractive error (
32231278
)
Tourette syndrome (
22889924
)
Basal cell carcinoma (
33549134
25855136
28177523
)
Breast cancer (
29059683
)
Chronic lymphocytic leukemia (
23770605
26956414
28165464
)
Cutaneous malignant melanoma (
32341527
)
Esophageal squamous cell carcinoma (
25129146
)
Lymphocyte count (
27863252
)
Melanoma (
28212542
21983787
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Non-small cell lung cancer (
31326317
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
)
Rheumatoid arthritis (
30423114
24390342
)
Spleen volume (
34128465
)
White blood cell count (
32888494
)
Interacting Genes
21 interacting genes:
AP2A1
ATXN1
ATXN1L
CASP3
CASP8
CDC42
CLTC
CLTCL1
CRX
DDIT3
EHD2
EPS15
FCHO1
ITSN1
OGT
PELI2
PLCG1
RBPMS
SMURF1
TENM1
ZC3H10
133 interacting genes:
AGR3
ANGPTL4
AP1M1
APAF1
APP
AR
ATAD2
ATG4D
ATP1A3
BAP1
BCAP31
BCL2
BCL2L1
BCL2L10
BEX1
BFAR
BID
BIRC6
BLID
BRD1
CASC3
CASP1
CASP10
CASP14
CASP2
CASP3
CASP4
CASP6
CASP7
CASP8AP2
CASP9
CCNL1
CDH1
CDH13
CDK11B
CDKN1B
CFLAR
CHD3
CHUK
CNBP
COPS6
CRADD
CTNNB1
DEDD
DEDD2
EDA2R
EIF2AK2
EPSTI1
ERRFI1
FADD
FAF1
FAS
FYN
GLCE
GMEB1
GREB1
GRIA1
GZMB
HBP1
HDAC7
HECTD3
HIP1
IKBKB
IKBKG
IL13RA2
IL24
ILK
KLK5
KLK9
KRT18
LYPD3
MAP1LC3B
MAP3K14
MAP4K4
MAPK1
MAPK3
MAPT
NOD1
NOL3
NR1H4
NSD3
OGT
PARK7
PARP1
PARP2
PCYT1A
PDIA6
PEA15
PIAS1
PICALM
PIK3C3
PLA2G4B
PLEC
PLIN4
PRDM14
PRDX6
PRKCI
PRKCZ
PRKN
PRSS50
PSEN1
PSEN2
PSMC3IP
QDPR
RALBP1
RB1
RIPK1
RIPK2
RNF31
RYBP
S100A14
SCGB2A2
SERPINB5
SNRPD3
SOX2
SRC
SRF
ST14
STK24
SUMO1
TFCP2
TNFRSF10A
TNFRSF10B
TOPORS
TRAF1
TRAF2
UBC
UMPS
USO1
VIM
VPS45
YBX1
ZNF707
Entrez ID
8301
841
HPRD ID
04320
03459
Ensembl ID
ENSG00000073921
ENSG00000064012
Uniprot IDs
Q13492
A0A8Q3SID9
Q14790
PDB IDs
1F9E
1I4E
1QDU
1QTN
2C2Z
2FUN
2K7Z
2Y1L
3H11
3KJN
3KJQ
4JJ7
4PRZ
4PS1
4ZBW
5H31
5H33
5JQE
5L08
6AGW
6PX9
7DEE
7LVJ
7LVM
8YBX
8YD7
8YD8
8YM4
8YM5
8YM6
8YNI
8YNK
8YNL
8YNM
8YNN
Enriched GO Terms of Interacting Partners
?
Postsynaptic Endocytic Zone
Clathrin-coated Pit
Clathrin-coated Vesicle
Endocytosis
Clathrin Coat Of Trans-Golgi Network Vesicle
Clathrin-dependent Endocytosis
Receptor-mediated Endocytosis
Import Into Cell
Clathrin Coat Assembly
Clathrin-coated Endocytic Vesicle
Cytosol
Intracellular Transport
Negative Regulation Of Hyaluronan Biosynthetic Process
POZ Domain Binding
Endosomal Transport
Cytosolic Transport
Pyroptotic Inflammatory Response
Response To Anesthetic
Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Transport
Cellular Localization
Vesicle-mediated Transport
Postsynaptic Neurotransmitter Receptor Internalization
Establishment Of Localization In Cell
Death-inducing Signaling Complex
Clathrin Complex
Clathrin Coat Of Coated Pit
Clathrin Light Chain Binding
Glutamatergic Synapse
Positive Regulation Of Pyroptotic Inflammatory Response
Response To Cobalt Ion
AP-2 Adaptor Complex
Positive Regulation Of Macromolecule Metabolic Process
Leucine Zipper Domain Binding
Positive Regulation Of Neuron Apoptotic Process
Receptor Internalization
Intracellular Protein Localization
Golgi To Endosome Transport
Vesicle-mediated Transport In Synapse
Death Receptor Binding
Positive Regulation Of Metabolic Process
Protein-containing Complex
Regulation Of Macromolecule Metabolic Process
Endolysosome Membrane
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Transport
Execution Phase Of Apoptosis
Regulation Of Vesicle-mediated Transport
Low-density Lipoprotein Particle Receptor Binding
Programmed Cell Death
Cell Death
Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Apoptotic Signaling Pathway
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Apoptotic Process
Intracellular Signal Transduction
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Extrinsic Apoptotic Signaling Pathway
Signal Transduction
Negative Regulation Of Programmed Cell Death
Cellular Response To Stress
Response To Stress
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Apoptotic Process
Cytosol
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Neuron Apoptotic Process
Cytoplasm
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cellular Response To Oxygen-containing Compound
Ubiquitin Protein Ligase Binding
Intrinsic Apoptotic Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cysteine-type Endopeptidase Activity
Protein Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Programmed Necrotic Cell Death
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