PICALM and CASP8

Number of citations of the paper that reports this interaction (PMID 10926122)
1

Data Source:
HPRD (in vitro)

		PICALM	CASP8
Gene Name		phosphatidylinositol binding clathrin assembly protein	caspase 8, apoptosis-related cysteine peptidase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Coated Pit Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neurofibrillary Tangle	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Microtubule Organizing Center Cytosol Cytoskeleton Noc1p-Noc2p Complex Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Clathrin Binding Clathrin Heavy Chain Binding Clathrin Adaptor Activity	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Ubiquitin Protein Ligase Binding Protein Complex Binding Death Effector Domain Binding Protein Heterodimerization Activity Scaffold Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Protein Complex Assembly Receptor-mediated Endocytosis Axonogenesis Cell Proliferation Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Cargo Loading Into Vesicle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Iron Ion Homeostasis Clathrin-mediated Endocytosis Iron Ion Import Into Cell Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Cold Viral Process Natural Killer Cell Activation Macrophage Differentiation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Response To Antibiotic Protein Heterooligomerization Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Regulation Of Thymocyte Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Activation Of Cysteine-type Endopeptidase Activity Hepatocyte Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	TRAIL signaling Death Receptor Signalling Caspase-8 activation by cleavage FasL/ CD95L signaling Activation, myristolyation of BID and translocation to mitochondria Caspase-mediated cleavage of cytoskeletal proteins Activated TLR4 signalling NOD1/2 Signaling Pathway Programmed Cell Death TRIF-mediated programmed cell death Innate Immune System Intrinsic Pathway for Apoptosis Regulation by c-FLIP Apoptotic cleavage of cellular proteins Dimerization of procaspase-8 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 19734902 21627779) Alzheimer's disease (late onset) ( 21460841) Tourette syndrome ( 22889924)	Melanoma ( 21983787)
Protein-Protein Interactions		10 interactors: AP2A1 CASP3 CASP8 CLTC CLTCL1 DDIT3 EHD2 ITSN1 PELI2 PLCG1	91 interactors: APAF1 APP AR ATG4D BCAP31 BCL2 BCL2L1 BFAR BID BIRC6 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CDH1 CDK11B CDKN1B CFLAR CHD3 CHUK COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 FADD FAF1 FAS FYN GMEB1 GRIA1 GZMB HDAC7 HECTD3 HIP1 IKBKB IKBKG ILK KRT18 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 PARK2 PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PLA2G4B PLEC PLIN4 PRDX6 PRKCI PRKCZ PSEN1 PSEN2 RALBP1 RB1 RIPK1 RIPK2 RYBP SNRPD3 SRF STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 TRAF6 USO1 VIM
Entrez ID		8301	841
HPRD ID		04320	03459
Ensembl ID		ENSG00000073921	ENSG00000064012
Uniprot IDs		Q13492	Q14790
PDB IDs			1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7
Enriched GO Terms of Interacting Partners?		Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Cell Morphogenesis Involved In Differentiation Cellular Localization Anatomical Structure Morphogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Phosphorus Metabolic Process Regulation Of Neuron Death Intracellular Transport Response To Organic Substance Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Intracellular Signal Transduction Signaling Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Phosphorylation Cell Communication Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Receptor-mediated Endocytosis Execution Phase Of Apoptosis Positive Regulation Of Neuron Death Negative Regulation Of Determination Of Dorsal Identity	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Processing Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Regulation Of Signal Transduction Regulation Of Peptidase Activity Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signaling Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Execution Phase Of Apoptosis Negative Regulation Of Cell Death Regulation Of Metabolic Process
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely	10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely	10mum abeta42 abeta43 aif carnosic cascades casp4 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Intersection) ?		casp3