PICALM and PLCG1

Number of citations of the paper that reports this interaction (PubMedID 10926122)
0

Data Source:
HPRD (in vitro)

		PICALM	PLCG1
Description		phosphatidylinositol binding clathrin assembly protein	phospholipase C gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Endomembrane System Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Presynaptic Membrane Neuronal Cell Body Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Ruffle Cytoplasm Cytosol Plasma Membrane COP9 Signalosome Lamellipodium Ruffle Membrane Cell Projection
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Small GTPase Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Protein Kinase Binding Metal Ion Binding Calcium-dependent Phospholipase C Activity Phosphatidylinositol Phospholipase C Activity
	Biological Process	Intracellular Iron Ion Homeostasis Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Vesicle Cargo Loading Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Multicellular Organismal-level Iron Ion Homeostasis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Localization To Cell Surface	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Lipid Catabolic Process Cell Migration Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RND3 GTPase cycle	ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Signaling by ALK Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Alzheimer's disease ( 19734902 21627779 22832961 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Chronic obstructive pulmonary disease ( 30804561) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Mean platelet volume ( 32888494) Platelet count ( 27863252 32888494) Refractive error ( 32231278) Tourette syndrome ( 22889924)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: AP2A1 ATXN1 ATXN1L CASP3 CASP8 CDC42 CLTC CLTCL1 CRX DDIT3 EHD2 EPS15 FCHO1 ITSN1 OGT PELI2 PLCG1 RBPMS SMURF1 TENM1 ZC3H10	112 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RBM11 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		8301	5335
HPRD ID		04320	01398
Ensembl ID		ENSG00000073921	ENSG00000124181
Uniprot IDs		Q13492	P19174
PDB IDs			1HSQ 2HSP 4EY0 4FBN 7NXE
Enriched GO Terms of Interacting Partners?		Postsynaptic Endocytic Zone Clathrin-coated Pit Clathrin-coated Vesicle Endocytosis Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-dependent Endocytosis Receptor-mediated Endocytosis Import Into Cell Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytosol Intracellular Transport Negative Regulation Of Hyaluronan Biosynthetic Process POZ Domain Binding Endosomal Transport Cytosolic Transport Pyroptotic Inflammatory Response Response To Anesthetic Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Transport Cellular Localization Vesicle-mediated Transport Postsynaptic Neurotransmitter Receptor Internalization Establishment Of Localization In Cell Death-inducing Signaling Complex Clathrin Complex Clathrin Coat Of Coated Pit Clathrin Light Chain Binding Glutamatergic Synapse Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion AP-2 Adaptor Complex Positive Regulation Of Macromolecule Metabolic Process Leucine Zipper Domain Binding Positive Regulation Of Neuron Apoptotic Process Receptor Internalization Intracellular Protein Localization Golgi To Endosome Transport Vesicle-mediated Transport In Synapse Death Receptor Binding Positive Regulation Of Metabolic Process Protein-containing Complex Regulation Of Macromolecule Metabolic Process Endolysosome Membrane Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Transport Execution Phase Of Apoptosis Regulation Of Vesicle-mediated Transport Low-density Lipoprotein Particle Receptor Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Plasma Membrane Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Phosphorylation Regulation Of Signal Transduction Protein Autophosphorylation Positive Regulation Of Signal Transduction Cell Migration Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Receptor Complex Antigen Receptor-mediated Signaling Pathway Cell Motility Activation Of Immune Response Immune System Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway ATP Binding Cell Activation Positive Regulation Of Cellular Component Organization Regulation Of Cell Population Proliferation Response To Growth Factor Developmental Process Nucleotide Binding Leukocyte Activation Regulation Of Immune Response Positive Regulation Of Immune System Process
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