FAHD1 and PAXIP1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		FAHD1	PAXIP1
Description		fumarylacetoacetate hydrolase domain containing 1	PAX interacting protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Catalytic Activity Protein Binding Oxaloacetate Decarboxylase Activity Hydrolase Activity Lyase Activity Isomerase Activity Acetylpyruvate Hydrolase Activity Fumarylpyruvate Hydrolase Activity Metal Ion Binding Acylpyruvate Hydrolase Activity Oxaloacetate Tautomerase Activity	Protein Binding
	Biological Process	Oxaloacetate Metabolic Process Carboxylic Acid Metabolic Process	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Pyruvate metabolism	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS			Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: BNIP2 EXOSC4 PAXIP1 PLPP1	90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B
Entrez ID		81889	22976
HPRD ID		13286	08491
Ensembl ID		ENSG00000180185	ENSG00000157212
Uniprot IDs		Q6P587	Q6ZW49
PDB IDs		1SAW 6FOG 6FOH	3SQD
Enriched GO Terms of Interacting Partners?		Spindle Pole Centrosome Response To Oxygen-glucose Deprivation Ceramide-1-phosphate Phosphatase Activity Diacylglycerol Diphosphate Phosphatase Activity Lipid Phosphatase Activity Phosphatidate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity MLL3/4 Complex Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Chorion Development Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Histone MRNA Catabolic Process Exosome (RNase Complex) Exoribonuclease Complex Nuclear Exosome (RNase Complex) RNA Exonuclease Activity Sno(s)RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Sphingosine Metabolic Process Maturation Of 5.8S RRNA Androgen Receptor Signaling Pathway SnRNA 3'-end Processing Histone MRNA Metabolic Process Diol Metabolic Process Histone Methyltransferase Complex Positive Regulation Of Isotype Switching MRNA 3'-UTR AU-rich Region Binding DNA Modification Blastocyst Development	Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex
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