FAHD1 and PLPP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FAHD1	PLPP1
Description		fumarylacetoacetate hydrolase domain containing 1	phospholipid phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Plasma Membrane Caveola Membrane Apical Plasma Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Catalytic Activity Protein Binding Oxaloacetate Decarboxylase Activity Hydrolase Activity Lyase Activity Isomerase Activity Acetylpyruvate Hydrolase Activity Fumarylpyruvate Hydrolase Activity Metal Ion Binding Acylpyruvate Hydrolase Activity Oxaloacetate Tautomerase Activity	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Ceramide-1-phosphate Phosphatase Activity
	Biological Process	Oxaloacetate Metabolic Process Carboxylic Acid Metabolic Process	Lipid Metabolic Process Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Lipid Metabolic Process Sphingolipid Catabolic Process Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Androgen Receptor Signaling Pathway Phospholipid Dephosphorylation
Pathways		Pyruvate metabolism	Sphingolipid catabolism
Drugs
Diseases
GWAS			Cocaine dependence ( 31212010) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		4 interacting genes: BNIP2 EXOSC4 PAXIP1 PLPP1	5 interacting genes: CREB3 FAHD1 FXYD1 GPR42 SSMEM1
Entrez ID		81889	8611
HPRD ID		13286	06178
Ensembl ID		ENSG00000180185	ENSG00000067113
Uniprot IDs		Q6P587	O14494
PDB IDs		1SAW 6FOG 6FOH
Enriched GO Terms of Interacting Partners?		Spindle Pole Centrosome Response To Oxygen-glucose Deprivation Ceramide-1-phosphate Phosphatase Activity Diacylglycerol Diphosphate Phosphatase Activity Lipid Phosphatase Activity Phosphatidate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity Sphingosine-1-phosphate Phosphatase Activity MLL3/4 Complex Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Chorion Development Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process Histone MRNA Catabolic Process Exosome (RNase Complex) Exoribonuclease Complex Nuclear Exosome (RNase Complex) RNA Exonuclease Activity Sno(s)RNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Sphingosine Metabolic Process Maturation Of 5.8S RRNA Androgen Receptor Signaling Pathway SnRNA 3'-end Processing Histone MRNA Metabolic Process Diol Metabolic Process Histone Methyltransferase Complex Positive Regulation Of Isotype Switching MRNA 3'-UTR AU-rich Region Binding DNA Modification Blastocyst Development	Negative Regulation Of Protein Glutathionylation Positive Regulation Of Deacetylase Activity Fumarylpyruvate Hydrolase Activity Oxaloacetate Tautomerase Activity Acylpyruvate Hydrolase Activity Acetylpyruvate Hydrolase Activity Positive Regulation Of Monoatomic Ion Transport Oxaloacetate Decarboxylase Activity Release From Viral Latency Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Regulation Of Cardiac Muscle Cell Membrane Potential CCR1 Chemokine Receptor Binding Oxaloacetate Metabolic Process CAMP Response Element Binding Protein Binding Sodium:potassium-exchanging ATPase Complex Regulation Of Metal Ion Transport Induction Of Positive Chemotaxis
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