SHARPIN and SHANK1

Number of citations of the paper that reports this interaction (PubMedID 11178875)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SHARPIN	SHANK1
Description		SHANK associated RH domain interactor	SH3 and multiple ankyrin repeat domains 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Synapse LUBAC Complex	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Dendrite Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding	G Protein-coupled Receptor Binding Protein Binding SH3 Domain Binding Signaling Receptor Complex Adaptor Activity Synaptic Receptor Adaptor Activity Somatostatin Receptor Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding Ankyrin Repeat Binding Scaffold Protein Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Mitochondrion Organization Epidermis Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Apoptotic Nuclear Changes Keratinization Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Nervous System Development Long-term Memory Associative Learning Cell Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Protein Localization To Synapse Olfactory Behavior Habituation Modulation Of Chemical Synaptic Transmission Synapse Organization Neuromuscular Process Controlling Balance Cognition Determination Of Affect Righting Reflex Synapse Maturation Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Vocalization Behavior AMPA Selective Glutamate Receptor Signaling Pathway Maintenance Of Postsynaptic Density Structure Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Neurexins and neuroligins	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Carotid plaque maximum area ( 32469969) Clozapine-induced cytotoxicity ( 25656473) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969)
Interacting Genes		30 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 PTEN RBCK1 RNF26 RNF31 SHANK1 SHANK2 SHANK3 TIAM1 TNF TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	23 interacting genes: ABCA1 ACE2 ADGRB2 ADGRL1 ADGRL2 ARHGEF7 BAIAP2 DLG4 DLGAP1 DNM2 FXR1 HOMER1 PRMT2 RPS6KA2 RPS6KA3 SHANK3 SHARPIN SPTAN1 SSTR2 STAT1 TANC1 TSC1 USP8
Entrez ID		81858	50944
HPRD ID		15463	05413
Ensembl ID		ENSG00000179526	ENSG00000161681
Uniprot IDs		Q6PJD5 Q9H0F6	H9KV90 Q9Y566
PDB IDs		4EMO 5X0W 8K6P	6CPI 6YWZ 6YX0 6YX1 6YX2 7A00 8S1R
Enriched GO Terms of Interacting Partners?		Integrin Complex Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Synaptic Receptor Adaptor Activity Cellular Extravasation Dendritic Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity Heterotypic Cell-cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Nervous System Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Social Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Signaling Receptor Activity Vocalization Behavior Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Meiotic Chromosome Movement Towards Spindle Pole Cell Adhesion Cell Surface Postsynaptic Specialization Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dopamine Metabolic Process Microglial Cell Activation LUBAC Complex Ionotropic Glutamate Receptor Binding Neuron Projection Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane RNA Strand Annealing Activity Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Positive Regulation Of Dendritic Spine Development Positive Regulation Of DNA-binding Transcription Factor Activity Postsynaptic Membrane Signal Transduction Intracellular Membraneless Organelle Regulation Of Neutrophil Degranulation	Synapse Postsynaptic Density Neuron Projection Regulation Of Cellular Component Organization Neuron Spine Glutamatergic Synapse Signal Transduction Dendritic Spine Latrotoxin Receptor Activity Cell Projection Modulation Of Chemical Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Postsynapse AMPA Glutamate Receptor Clustering Neuron Projection Organization Ribosomal Protein S6 Kinase Activity Postsynapse Organization Regulation Of Postsynapse Organization Modulation Of Excitatory Postsynaptic Potential Regulation Of Synapse Organization Chemical Synaptic Transmission Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Trans-synaptic Signaling Synaptic Signaling TORC1 Signaling Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Plasma Membrane Scaffold Protein Binding Regulation Of Cell Communication Regulation Of Signaling Endocytic Vesicle Membrane Positive Regulation Of Signal Transduction Neurotransmitter-gated Ion Channel Clustering Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Plasticity Axon Regulation Of Signal Transduction PDZ Domain Binding Costamere Cytosol TOR Signaling Regulation Of Biological Quality Positive Regulation Of Developmental Process Postsynaptic Membrane
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