SHARPIN

Gene Name		SHANK-associated RH domain interactor
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex
	Molecular Function	Protein Binding Zinc Ion Binding Polyubiquitin Binding Protein Complex Binding Identical Protein Binding
	Biological Process	Mitochondrion Organization Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Inflammatory Response Protein Homooligomerization Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		10 interactors: ITGA1 ITGA2 ITGAD ITGAL ITGAM SHANK1 SHANK2 TXN2 UBC UBE2D3
Entrez ID		81858
HPRD ID		15463
Ensembl ID		ENSG00000179526
Uniprot IDs		Q6PJD5 Q9H0F6
PDB IDs		4EMO
Enriched GO Terms of Interacting Partners?		Integrin-mediated Signaling Pathway Activated T Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization T Cell Proliferation Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Response To Wounding Toll-like Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Immune System Process Vocalization Behavior Blood Coagulation Pattern Recognition Receptor Signaling Pathway Hemostasis Innate Immune Response-activating Signal Transduction Cell Communication Activation Of Innate Immune Response Cell-matrix Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Adhesion Cellular Extravasation Regulation Of Body Fluid Levels Positive Regulation Of Phosphatase Activity Wound Healing Cell-substrate Adhesion Immune System Process Immune Response Regulation Of Immune System Process Leukocyte Migration Response To Stress Regulation Of Innate Immune Response Social Behavior Cell Proliferation Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Dephosphorylation Negative Regulation Of ERBB Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Neutrophil Chemotaxis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Neutrophil Migration Regulation Of DNA-templated Transcription In Response To Stress
Tagcloud ?		1l chain composed conjugation consists deeply elusive fluorescein fret fungal gliotoxin hoil hoip hts ibr linear lubac malignancy metabolite modulator nemo ring searched selectively tb3 termini though throughput ubiquitin