SHARPIN and ITGAD

Number of citations of the paper that reports this interaction (PubMedID 24210817)
38

Data Source:
BioGRID (unspecified method)

		SHARPIN	ITGAD
Description		SHANK associated RH domain interactor	integrin subunit alpha D
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Synapse LUBAC Complex	Plasma Membrane Integrin Complex Cell Surface Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding	Signaling Receptor Activity Metal Ion Binding
	Biological Process	Mitochondrion Organization Epidermis Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Apoptotic Nuclear Changes Keratinization Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion Cell-cell Adhesion
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Neurexins and neuroligins	Integrin cell surface interactions
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		30 interacting genes: ACTR2 ACTR3 FMR1 FXR1 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 PTEN RBCK1 RNF26 RNF31 SHANK1 SHANK2 SHANK3 TIAM1 TNF TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	4 interacting genes: ICAM3 ITGB2 SHARPIN VCAM1
Entrez ID		81858	3681
HPRD ID		15463	11785
Ensembl ID		ENSG00000179526	ENSG00000156886
Uniprot IDs		Q6PJD5 Q9H0F6	Q13349 Q59H14
PDB IDs		4EMO 5X0W 8K6P
Enriched GO Terms of Interacting Partners?		Integrin Complex Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Synaptic Receptor Adaptor Activity Cellular Extravasation Dendritic Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity Heterotypic Cell-cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Nervous System Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Social Behavior Dendritic Spine Morphogenesis Postsynaptic Density Organization Signaling Receptor Activity Vocalization Behavior Regulation Of Translation At Presynapse, Modulating Synaptic Transmission ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Meiotic Chromosome Movement Towards Spindle Pole Cell Adhesion Cell Surface Postsynaptic Specialization Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cognition Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dopamine Metabolic Process Microglial Cell Activation LUBAC Complex Ionotropic Glutamate Receptor Binding Neuron Projection Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Leukocyte Activation Involved In Inflammatory Response External Side Of Plasma Membrane RNA Strand Annealing Activity Negative Regulation Of Catecholamine Metabolic Process Regulation Of Neurogenesis Positive Regulation Of Neurogenesis Positive Regulation Of Dendritic Spine Development Positive Regulation Of DNA-binding Transcription Factor Activity Postsynaptic Membrane Signal Transduction Intracellular Membraneless Organelle Regulation Of Neutrophil Degranulation	Integrin Binding Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Cell-cell Adhesion Phagocytosis Cell-matrix Adhesion Cell Adhesion Molecule Binding Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Cell Adhesion Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Cell-substrate Adhesion Integrin AlphaL-beta2 Complex Peripheral Nervous System Neuron Differentiation ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Chemotaxis Negative Regulation Of Dopamine Metabolic Process LUBAC Complex Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Regulation Of Neutrophil Degranulation Positive Regulation Of Leukocyte Cell-cell Adhesion Primary Methylamine Oxidase Activity Cell-cell Adhesion Mediated By Integrin Apoptotic Nuclear Changes Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway Defense Response Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Chemotaxis Positive Regulation Of Cell-cell Adhesion Chronic Inflammatory Response External Side Of Plasma Membrane Locomotion Complement Component C3b Binding Cell Adhesion Mediator Activity Regulation Of Leukocyte Cell-cell Adhesion Endocytosis Regulation Of Dopamine Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Leukocyte Migration Involved In Inflammatory Response Cellular Extravasation Innervation Leukocyte Tethering Or Rolling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?