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SHARPIN and ITGA1
Number of citations of the paper that reports this interaction (PMID
21947080
)
27
Data Source:
BioGRID
(affinity chromatography technology, pull down)
SHARPIN
ITGA1
Gene Name
SHANK-associated RH domain interactor
integrin, alpha 1
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Postsynaptic Density
Cell Junction
Dendrite
LUBAC Complex
Acrosomal Vesicle
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Integrin Alpha1-beta1 Complex
Neuron Projection
Perikaryon
Membrane Raft
Basal Part Of Cell
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Polyubiquitin Binding
Protein Complex Binding
Identical Protein Binding
Receptor Binding
Protein Binding
Collagen Binding
Protein Phosphatase Binding
Metal Ion Binding
Collagen Binding Involved In Cell-matrix Adhesion
Biological Process
Mitochondrion Organization
Brain Development
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Apoptotic Nuclear Changes
Keratinization
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Inflammatory Response
Protein Homooligomerization
Protein Linear Polyubiquitination
Regulation Of CD40 Signaling Pathway
Activation Of MAPK Activity
Muscle Contraction
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Axon Guidance
Blood Coagulation
Negative Regulation Of Cell Proliferation
Extracellular Matrix Organization
Neutrophil Chemotaxis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Vasodilation
Positive Regulation Of Neuron Apoptotic Process
Cellular Extravasation
Pathways
Platelet Adhesion to exposed collagen
CHL1 interactions
Axon guidance
Laminin interactions
Semaphorin interactions
Other semaphorin interactions
Smooth Muscle Contraction
L1CAM interactions
Integrin cell surface interactions
Drugs
Diseases
GWAS
Alzheimer's disease biomarkers (
23419831
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Pulmonary function (
21946350
)
Pulmonary function (interaction) (
23284291
)
Response to platinum-based agents (
22020760
)
Protein-Protein Interactions
10 interactors:
ITGA1
ITGA2
ITGAD
ITGAL
ITGAM
SHANK1
SHANK2
TXN2
UBC
UBE2D3
10 interactors:
AUP1
BIN1
COL13A1
COL8A1
ITGB1
LAMA1
MATN1
PTPN2
SHARPIN
TLN1
Entrez ID
81858
3672
HPRD ID
15463
01892
Ensembl ID
ENSG00000179526
Uniprot IDs
Q6PJD5
Q9H0F6
P56199
PDB IDs
4EMO
1PT6
1QC5
1QCY
2L8S
4A0Q
Enriched GO Terms of Interacting Partners
?
Integrin-mediated Signaling Pathway
Activated T Cell Proliferation
Extracellular Matrix Organization
Extracellular Structure Organization
T Cell Proliferation
Toll-like Receptor 4 Signaling Pathway
Response To Hypoxia
Response To Wounding
Toll-like Receptor Signaling Pathway
Lymphocyte Proliferation
Mononuclear Cell Proliferation
Leukocyte Proliferation
Positive Regulation Of Immune System Process
Vocalization Behavior
Blood Coagulation
Pattern Recognition Receptor Signaling Pathway
Hemostasis
Innate Immune Response-activating Signal Transduction
Cell Communication
Activation Of Innate Immune Response
Cell-matrix Adhesion
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Innate Immune Response
Cell Surface Receptor Signaling Pathway
Cell Adhesion
Cellular Extravasation
Regulation Of Body Fluid Levels
Positive Regulation Of Phosphatase Activity
Wound Healing
Cell-substrate Adhesion
Immune System Process
Immune Response
Regulation Of Immune System Process
Leukocyte Migration
Response To Stress
Regulation Of Innate Immune Response
Social Behavior
Cell Proliferation
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Dephosphorylation
Negative Regulation Of ERBB Signaling Pathway
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Leukocyte Aggregation
Neutrophil Chemotaxis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Neutrophil Migration
Regulation Of DNA-templated Transcription In Response To Stress
Cell Differentiation
Extracellular Matrix Organization
Extracellular Structure Organization
System Development
Multicellular Organismal Development
Anatomical Structure Development
Cell Adhesion
Developmental Process
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Organ Development
Single Organismal Cell-cell Adhesion
Regulation Of Cell Adhesion
Anatomical Structure Morphogenesis
Cell Morphogenesis Involved In Differentiation
Tissue Development
Collagen Catabolic Process
Cellular Component Assembly
Organ Morphogenesis
Axon Guidance
Negative Regulation Of Interleukin-4-mediated Signaling Pathway
Negative Regulation Of Prolactin Signaling Pathway
Negative Regulation Of Positive Thymic T Cell Selection
Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein
Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway
Growth Plate Cartilage Chondrocyte Morphogenesis
Negative Regulation Of Interleukin-2-mediated Signaling Pathway
Collagen Metabolic Process
Cell Morphogenesis
Blood Vessel Morphogenesis
Endochondral Bone Morphogenesis
Multicellular Organismal Macromolecule Metabolic Process
Multicellular Organismal Metabolic Process
Extracellular Matrix Disassembly
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Endocytosis
B Cell Differentiation
Negative Regulation Of Inflammatory Response
Blood Vessel Development
Nervous System Development
Lipid Tube Assembly
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Negative Regulation Of Interleukin-6-mediated Signaling Pathway
Positive Regulation Of Cell-substrate Adhesion
Cell-cell Junction Assembly
Axonogenesis
Vasculature Development
Bone Morphogenesis
Axon Development
Formation Of Primary Germ Layer
Tagcloud
?
1l
chain
composed
conjugation
consists
deeply
elusive
fluorescein
fret
fungal
gliotoxin
hoil
hoip
hts
ibr
linear
lubac
malignancy
metabolite
modulator
nemo
ring
searched
selectively
tb3
termini
though
throughput
ubiquitin
Tagcloud (Difference)
?
1l
chain
composed
conjugation
consists
deeply
elusive
fluorescein
fret
fungal
gliotoxin
hoil
hoip
hts
ibr
linear
lubac
malignancy
metabolite
modulator
nemo
ring
searched
selectively
tb3
termini
though
throughput
ubiquitin
Tagcloud (Intersection)
?