TSC22D4 and FBXW7

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		TSC22D4	FBXW7
Description		TSC22 domain family member 4	F-box and WD repeat domain containing 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Dendrite Cell Projection Synapse	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Glucose Homeostasis Negative Regulation Of DNA-templated Transcription Neuron Cellular Homeostasis Neuron Projection Extension	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development
Pathways			Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		61 interacting genes: ABLIM1 AIFM1 ARHGAP9 BLZF1 CBX8 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU CTNNAL1 ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO1 LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP MYO15B NIF3L1 NOC4L NRBP1 PCBP1 PCDH17 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TRIM55 TRIM63 TSC22D1 TSPOAP1 UBLCP1 VBP1 ZBTB24 ZMYND10 ZNF580	84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510
Entrez ID		81628	55294
HPRD ID		18231	05888
Ensembl ID		ENSG00000166925	ENSG00000109670
Uniprot IDs		B4DKI8 Q9Y3Q8	G0Z2K0 Q969H0 S4R3U4
PDB IDs			2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Binding Organelle Organization Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Cytoplasm Negative Regulation Of Protein Metabolic Process Regulation Of Protein Stability Negative Regulation Of Amyloid-beta Formation Cellular Response To Glucose Stimulus Phosphothreonine Residue Binding Cellular Response To Hydrogen Peroxide Protein Localization To Lipid Droplet Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Glucose Mediated Signaling Pathway Regulation Of Glucose Mediated Signaling Pathway Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Carbohydrate Stimulus Organelle Disassembly Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Regulation Of Amide Metabolic Process Protein Stabilization Regulation Of Protein Metabolic Process Viral RNA Genome Replication Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Intracellular Glucose Homeostasis Protein Ubiquitination Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Response To Hydrogen Peroxide Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Ubiquitin-protein Transferase Activator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Release Of Cytochrome C From Mitochondria	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process
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