TSC22D4 and SMAD3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TSC22D4	SMAD3
Gene Name		TSC22 domain family, member 4	SMAD family member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Receptor Complex SMAD Protein Complex SMAD2-SMAD3 Protein Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding Protein Binding Transcription Factor Activity RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Collagen Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Enhancer Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Co-SMAD Binding R-SMAD Binding
	Biological Process	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Somitogenesis Liver Development Negative Regulation Of Protein Phosphorylation Heart Looping Osteoblast Development Immune System Development Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Endoderm Development Embryonic Pattern Specification Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Evasion Or Tolerance Of Host Defenses By Virus Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Primary MiRNA Processing Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Transforming Growth Factor Beta3 Production Activin Receptor Signaling Pathway Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Catenin Import Into Nucleus Intracellular Signal Transduction Nodal Signaling Pathway Wound Healing T Cell Activation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Immune Response Protein Stabilization Positive Regulation Of Positive Chemotaxis Regulation Of Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Pericardium Development Transdifferentiation SMAD Protein Signal Transduction Negative Regulation Of Wound Healing Lens Fiber Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Asthma ( 20860503) Corneal structure ( 23291589) Coronary heart disease ( 17634449) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580	268 interactors: AATF ACTB AES AKT1 ANAPC10 ANK3 APMAP APOB APP AR ARHGEF6 ATF2 ATF3 AXIN1 AXIN2 BLZF1 BPTF BRCA1 BRCA2 BTRC C10orf54 CAMK2G CCDC33 CDC16 CDC25A CDC27 CDK2 CDK4 CDK8 CDK9 CEBPA CEBPB CEBPD CFDP1 CFH CFLAR CHRD CLASRP CORO1A CPSF7 CPTP CREBBP CSH2 CSNK1D CSNK1G2 CTCF CTNNB1 CUL1 CXXC5 CYP11A1 DAB2 DACH1 DDX5 DEDD DNAJB4 DVL1 E2F4 E2F5 EBI3 EID2 EIF4ENIF1 EP300 EPAS1 EPB41 ERBB2IP ESR1 ESR2 ETS1 FBLN1 FHL2 FHL3 FLI1 FLNA FOS FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 GGA1 GIT2 GLI3 GMEB1 GSC GSK3B GTF2IRD1 HDAC1 HDAC4 HDAC5 HEY1 HEYL HGS HIPK2 HIVEP1 HMGA2 HNF4A HNRNPK HOXC11 HP HSPA4 IL37 ISL1 ITCH JPH3 JUN JUNB JUND KANSL1 KAT2B KDM2A KMT2B KPNB1 KRT10 KRT2 LBP LCK LEF1 LMNA MAGI2 MAP3K7 MAPK1 MAPK14 MAPK8 MAPK9 MAX MBD1 MCM3AP MDM4 MECOM MED15 MEN1 MEOX2 MTF2 MYC MYD88 MYO5B MYOCD MYOD1 NCOA6 NEDD4 NEDD4L NEDD9 NF1 NFYC NOTCH1 NOTCH4 NR3C1 NR4A1 NUP153 NUP214 OTUB1 PAEP PAPPA PARD3 PARD3B PARP4 PAX8 PCDH1 PCK2 PEX6 PHC2 PIAS2 PIAS3 PIAS4 PIK3CA PIN1 PLAG1 PLAGL1 PLG PML PPM1A PPP1R12C PPP2R1A PRDM4 PRKAR1B PRKAR2A PROX1 PRTN3 PSMD11 RAB38 RANBP9 RARG RASD2 RASL12 RBL1 RBX1 RCVRN RELA RIOK2 RIT1 RNF111 RNF31 RPA1 RPLP0 RRAS2 RUNX2 RUNX3 S100A4 SAP130 SERTAD1 SETD2 SF3A1 SF3B2 SIN3A SKI SKIL SKOR2 SMAD1 SMAD2 SMAD4 SMAD9 SMURF1 SMURF2 SNRNP70 SNW1 SP1 SPTBN1 SQSTM1 SREBF2 SRY SS18L1 ST6GALNAC2 STRAP STUB1 SVEP1 TANK TDP2 TEKT4 TF TFE3 TGFBR1 TGFBR2 TGIF1 TGIF2 TGM2 TLR4 TMED1 TOB1 TP53 TP73 TPM3 TSC2 TSC22D4 UBQLN4 UCHL5 USP15 USP7 VDR VIM WEE1 WWP1 WWP2 XRCC6 YBX1 YY1 ZBTB16 ZBTB3 ZC3H12A ZCCHC14 ZDHHC4 ZEB1 ZEB2 ZFYVE9 ZMYM2 ZMYND11 ZNF329 ZNF8 ZNF83
Entrez ID		81628	4088
HPRD ID		18231	04380
Ensembl ID		ENSG00000166925	ENSG00000166949
Uniprot IDs		A8MWR6 Q9Y3Q8	P84022 Q9P0T0
PDB IDs			1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Response To Growth Factor Cellular Response To Organic Substance RNA Metabolic Process Gene Expression Response To Organic Substance Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stimulus Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Organ Development Signal Transduction Developmental Process
Tagcloud ?		ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting	adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad4 smads squelching tgf transactivation transduce
Tagcloud (Difference) ?		ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting	adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad4 smads squelching tgf transactivation transduce
Tagcloud (Intersection) ?